Autocrine IL-6/STAT3 signaling aids development of acquired drug resistance in Group 3 medulloblastoma

Medulloblastoma (MB) is a high-grade pediatric brain malignancy that originates from neuronal precursors located in the posterior cranial fossa. In this study, we evaluated the role of STAT3 and IL-6 in a tumor microenvironment mediated drug resistance in human MBs. We established that the Group 3 M...

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Detalles Bibliográficos
Autores principales: Sreenivasan, Lakshana, Wang, Hui, Yap, Shyong Quin, Leclair, Pascal, Tam, Anthony, Lim, Chinten James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719195/
https://www.ncbi.nlm.nih.gov/pubmed/33279931
http://dx.doi.org/10.1038/s41419-020-03241-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719195/
https://www.ncbi.nlm.nih.gov/pubmed/33279931
http://dx.doi.org/10.1038/s41419-020-03241-y

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