HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper

This discussion paper addresses the safety of HIV cure studies, particularly those involving stopping antiretroviral therapy, known as an analytic treatment interruption (ATI) in the context of the SARS-CoV-2 pandemic. More than 30 studies listed on ClinicalTrials.gov include an ATI and many others...

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Autores principales: Fidler, S., Lewin, S., Deeks, S., Sogaard, O.S., Vanderkerckhove, L., Collins, S., Kelly, D., Singh, J., Caskey, M., Frater, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719279/
https://www.ncbi.nlm.nih.gov/pubmed/33312681
http://dx.doi.org/10.1016/j.jve.2020.100025
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author Fidler, S.
Lewin, S.
Deeks, S.
Sogaard, O.S.
Vanderkerckhove, L.
Collins, S.
Kelly, D.
Singh, J.
Caskey, M.
Frater, J.
author_facet Fidler, S.
Lewin, S.
Deeks, S.
Sogaard, O.S.
Vanderkerckhove, L.
Collins, S.
Kelly, D.
Singh, J.
Caskey, M.
Frater, J.
author_sort Fidler, S.
collection PubMed
description This discussion paper addresses the safety of HIV cure studies, particularly those involving stopping antiretroviral therapy, known as an analytic treatment interruption (ATI) in the context of the SARS-CoV-2 pandemic. More than 30 studies listed on ClinicalTrials.gov include an ATI and many others were planned to begin over the next 12 months but most were halted due to the COVID-19 pandemic. We consider the ethics, risks and practical considerations to be taken into account before re-opening HIV cure clinical trials, noting the specific risks of ATI in the context of circulating SARS-CoV-2.
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spelling pubmed-77192792020-12-07 HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper Fidler, S. Lewin, S. Deeks, S. Sogaard, O.S. Vanderkerckhove, L. Collins, S. Kelly, D. Singh, J. Caskey, M. Frater, J. J Virus Erad Viewpoint This discussion paper addresses the safety of HIV cure studies, particularly those involving stopping antiretroviral therapy, known as an analytic treatment interruption (ATI) in the context of the SARS-CoV-2 pandemic. More than 30 studies listed on ClinicalTrials.gov include an ATI and many others were planned to begin over the next 12 months but most were halted due to the COVID-19 pandemic. We consider the ethics, risks and practical considerations to be taken into account before re-opening HIV cure clinical trials, noting the specific risks of ATI in the context of circulating SARS-CoV-2. Elsevier 2020-12-06 /pmc/articles/PMC7719279/ /pubmed/33312681 http://dx.doi.org/10.1016/j.jve.2020.100025 Text en © 2020 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Viewpoint
Fidler, S.
Lewin, S.
Deeks, S.
Sogaard, O.S.
Vanderkerckhove, L.
Collins, S.
Kelly, D.
Singh, J.
Caskey, M.
Frater, J.
HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper
title HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper
title_full HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper
title_fullStr HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper
title_full_unstemmed HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper
title_short HIV cure research in the time of COVID-19 - Antiretroviral therapy treatment interruption trials: A discussion paper
title_sort hiv cure research in the time of covid-19 - antiretroviral therapy treatment interruption trials: a discussion paper
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719279/
https://www.ncbi.nlm.nih.gov/pubmed/33312681
http://dx.doi.org/10.1016/j.jve.2020.100025
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