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Developing a Kinase-Specific Target Selection Method Using a Structure-Based Machine Learning Approach
INTRODUCTION: Despite recent advances in the drug discovery field, developing selective kinase inhibitors remains a complicated issue for a number of reasons, one of which is that there are striking structural similarities in the ATP-binding pockets of kinases. OBJECTIVE: To address this problem, we...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719317/ https://www.ncbi.nlm.nih.gov/pubmed/33293834 http://dx.doi.org/10.2147/AABC.S278900 |