Interindividual Variability in Lymphocyte Stimulation and Transcriptomic Response Predicts Mycophenolic Acid Sensitivity in Healthy Volunteers

Mycophenolic acid (MPA) is an immunosuppressant commonly used to prevent renal transplant rejection and treat glomerulonephritis. MPA inhibits IMPDH2 within stimulated lymphocytes, reducing guanosine synthesis. Despite the widespread use of MPA, interindividual variability in response remains with r...

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Detalles Bibliográficos
Autores principales: Collins, Kimberly S., Cheng, Ying‐Hua, Ferreira, Ricardo M., Gao, Hongyu, Dollins, Matthew D., Janosevic, Danielle, Khan, Nida A., White, Chloe, Dagher, Pierre C., Eadon, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719379/
https://www.ncbi.nlm.nih.gov/pubmed/32415749
http://dx.doi.org/10.1111/cts.12795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719379/
https://www.ncbi.nlm.nih.gov/pubmed/32415749
http://dx.doi.org/10.1111/cts.12795

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