Systemic Lupus Erythematosus Activity Affects the Sinusoidal Uptake Transporter OATP1B1 Evaluated by the Pharmacokinetics of Atorvastatin

The present study assessed the effect of systemic lupus erythematosus (SLE) activity, a chronic and inflammatory autoimmune disease, on the sinusoidal uptake transporter OATP1B1 using atorvastatin (ATV) as a probe drug. Fifteen healthy subjects, 13 patients with controlled SLE (SLEDAI 0–4), and 12 p...

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Detalles Bibliográficos
Autores principales: Cestari, Roberta Natália, de Oliveira, Renê Donizeti Ribeiro, de Souza, Flávio Falcão Lima, Pippa, Leandro Francisco, Nardotto, Glauco Henrique Balthazar, Rocha, Adriana, Donadi, Eduardo Antônio, Lanchote, Vera Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719393/
https://www.ncbi.nlm.nih.gov/pubmed/32463566
http://dx.doi.org/10.1111/cts.12808

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