Sphingosine kinase 1 regulates HMGB1 translocation by directly interacting with calcium/calmodulin protein kinase II-δ in sepsis-associated liver injury

Previously, we confirmed that sphingosine kinase 1 (SphK1) inhibition improves sepsis-associated liver injury. High-mobility group box 1 (HMGB1) translocation participates in the development of acute liver failure. However, little information is available on the association between SphK1 and HMGB1 t...

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Detalles Bibliográficos
Autores principales: Tian, Tao, Yao, Danhua, Zheng, Lei, Zhou, Zhiyuan, Duan, Yantao, Liu, Bin, Wang, Pengfei, Li, Yousheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719708/
https://www.ncbi.nlm.nih.gov/pubmed/33281190
http://dx.doi.org/10.1038/s41419-020-03255-6

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