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MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs
MicroRNAs regulate gene expression at post-transcriptional levels. Some of them appear to regulate brain development and are involved in neurodevelopmental disorders. This has led to the suggestion that the role of microRNAs in neuronal development and function may be more central than previously ap...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719755/ https://www.ncbi.nlm.nih.gov/pubmed/33330463 http://dx.doi.org/10.3389/fcell.2020.586158 |
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author | Alwin Prem Anand, A. Alvarez-Bolado, Gonzalo Wizenmann, Andrea |
author_facet | Alwin Prem Anand, A. Alvarez-Bolado, Gonzalo Wizenmann, Andrea |
author_sort | Alwin Prem Anand, A. |
collection | PubMed |
description | MicroRNAs regulate gene expression at post-transcriptional levels. Some of them appear to regulate brain development and are involved in neurodevelopmental disorders. This has led to the suggestion that the role of microRNAs in neuronal development and function may be more central than previously appreciated. Here, we review the data about miR-9 function to depict the subtlety, complexity, flexibility and limited functional conservation of this essential developmental regulatory system. On this basis we propose that species-specific actions of miR-9 could underlie to a large degree species differences in brain size, shape and function. |
format | Online Article Text |
id | pubmed-7719755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77197552020-12-15 MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs Alwin Prem Anand, A. Alvarez-Bolado, Gonzalo Wizenmann, Andrea Front Cell Dev Biol Cell and Developmental Biology MicroRNAs regulate gene expression at post-transcriptional levels. Some of them appear to regulate brain development and are involved in neurodevelopmental disorders. This has led to the suggestion that the role of microRNAs in neuronal development and function may be more central than previously appreciated. Here, we review the data about miR-9 function to depict the subtlety, complexity, flexibility and limited functional conservation of this essential developmental regulatory system. On this basis we propose that species-specific actions of miR-9 could underlie to a large degree species differences in brain size, shape and function. Frontiers Media S.A. 2020-11-23 /pmc/articles/PMC7719755/ /pubmed/33330463 http://dx.doi.org/10.3389/fcell.2020.586158 Text en Copyright © 2020 Alwin Prem Anand, Alvarez-Bolado and Wizenmann. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Alwin Prem Anand, A. Alvarez-Bolado, Gonzalo Wizenmann, Andrea MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs |
title | MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs |
title_full | MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs |
title_fullStr | MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs |
title_full_unstemmed | MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs |
title_short | MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs |
title_sort | mir-9 and the midbrain-hindbrain boundary: a showcase for the limited functional conservation and regulatory complexity of micrornas |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719755/ https://www.ncbi.nlm.nih.gov/pubmed/33330463 http://dx.doi.org/10.3389/fcell.2020.586158 |
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