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MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs

MicroRNAs regulate gene expression at post-transcriptional levels. Some of them appear to regulate brain development and are involved in neurodevelopmental disorders. This has led to the suggestion that the role of microRNAs in neuronal development and function may be more central than previously ap...

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Autores principales: Alwin Prem Anand, A., Alvarez-Bolado, Gonzalo, Wizenmann, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719755/
https://www.ncbi.nlm.nih.gov/pubmed/33330463
http://dx.doi.org/10.3389/fcell.2020.586158
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author Alwin Prem Anand, A.
Alvarez-Bolado, Gonzalo
Wizenmann, Andrea
author_facet Alwin Prem Anand, A.
Alvarez-Bolado, Gonzalo
Wizenmann, Andrea
author_sort Alwin Prem Anand, A.
collection PubMed
description MicroRNAs regulate gene expression at post-transcriptional levels. Some of them appear to regulate brain development and are involved in neurodevelopmental disorders. This has led to the suggestion that the role of microRNAs in neuronal development and function may be more central than previously appreciated. Here, we review the data about miR-9 function to depict the subtlety, complexity, flexibility and limited functional conservation of this essential developmental regulatory system. On this basis we propose that species-specific actions of miR-9 could underlie to a large degree species differences in brain size, shape and function.
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spelling pubmed-77197552020-12-15 MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs Alwin Prem Anand, A. Alvarez-Bolado, Gonzalo Wizenmann, Andrea Front Cell Dev Biol Cell and Developmental Biology MicroRNAs regulate gene expression at post-transcriptional levels. Some of them appear to regulate brain development and are involved in neurodevelopmental disorders. This has led to the suggestion that the role of microRNAs in neuronal development and function may be more central than previously appreciated. Here, we review the data about miR-9 function to depict the subtlety, complexity, flexibility and limited functional conservation of this essential developmental regulatory system. On this basis we propose that species-specific actions of miR-9 could underlie to a large degree species differences in brain size, shape and function. Frontiers Media S.A. 2020-11-23 /pmc/articles/PMC7719755/ /pubmed/33330463 http://dx.doi.org/10.3389/fcell.2020.586158 Text en Copyright © 2020 Alwin Prem Anand, Alvarez-Bolado and Wizenmann. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Alwin Prem Anand, A.
Alvarez-Bolado, Gonzalo
Wizenmann, Andrea
MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs
title MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs
title_full MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs
title_fullStr MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs
title_full_unstemmed MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs
title_short MiR-9 and the Midbrain-Hindbrain Boundary: A Showcase for the Limited Functional Conservation and Regulatory Complexity of MicroRNAs
title_sort mir-9 and the midbrain-hindbrain boundary: a showcase for the limited functional conservation and regulatory complexity of micrornas
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719755/
https://www.ncbi.nlm.nih.gov/pubmed/33330463
http://dx.doi.org/10.3389/fcell.2020.586158
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