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Multimodal Computational Modeling of Visual Object Recognition Deficits but Intact Repetition Priming in Schizophrenia

The term perceptual closure refers to the neural processes responsible for “filling-in” missing information in the visual image under highly adverse viewing conditions such as fog or camouflage. Here we used a closure task that required the participants to identify barely recognizable fragmented lin...

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Autores principales: Sehatpour, Pejman, Bassir Nia, Anahita, Adair, Devin, Wang, Zhishun, DeBaun, Heloise M., Silipo, Gail, Martinez, Antigona, Javitt, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719812/
https://www.ncbi.nlm.nih.gov/pubmed/33329086
http://dx.doi.org/10.3389/fpsyt.2020.547189
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author Sehatpour, Pejman
Bassir Nia, Anahita
Adair, Devin
Wang, Zhishun
DeBaun, Heloise M.
Silipo, Gail
Martinez, Antigona
Javitt, Daniel C.
author_facet Sehatpour, Pejman
Bassir Nia, Anahita
Adair, Devin
Wang, Zhishun
DeBaun, Heloise M.
Silipo, Gail
Martinez, Antigona
Javitt, Daniel C.
author_sort Sehatpour, Pejman
collection PubMed
description The term perceptual closure refers to the neural processes responsible for “filling-in” missing information in the visual image under highly adverse viewing conditions such as fog or camouflage. Here we used a closure task that required the participants to identify barely recognizable fragmented line-drawings of common objects. Patients with schizophrenia have been shown to perform poorly on this task. Following priming, controls and importantly patients can complete the line-drawings at greater levels of fragmentation behaviorally, suggesting an improvement in their ability to perform the task. Closure phenomena have been shown to involve a distributed network of cortical regions, notably the lateral occipital complex (LOC) of the ventral visual stream, dorsal visual stream (DS), hippocampal formation (HIPP) and the prefrontal cortex (PFC). We have previously demonstrated the failure of closure processes in schizophrenia and shown that the dysregulation in the sensory information transmitted to the prefrontal cortex plays a critical role in this failure. Here, using a multimodal imaging approach in patients, combining event related electrophysiological recordings (ERP) and functional magnetic resonance imaging (fMRI), we characterize the spatiotemporal dynamics of priming in perceptual closure. Using directed functional connectivity measures we demonstrate that priming modifies the network-level interactions between the nodes of closure processing in a manner that is functionally advantageous to patients resulting in the mitigation of their deficit in perceptual closure.
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spelling pubmed-77198122020-12-15 Multimodal Computational Modeling of Visual Object Recognition Deficits but Intact Repetition Priming in Schizophrenia Sehatpour, Pejman Bassir Nia, Anahita Adair, Devin Wang, Zhishun DeBaun, Heloise M. Silipo, Gail Martinez, Antigona Javitt, Daniel C. Front Psychiatry Psychiatry The term perceptual closure refers to the neural processes responsible for “filling-in” missing information in the visual image under highly adverse viewing conditions such as fog or camouflage. Here we used a closure task that required the participants to identify barely recognizable fragmented line-drawings of common objects. Patients with schizophrenia have been shown to perform poorly on this task. Following priming, controls and importantly patients can complete the line-drawings at greater levels of fragmentation behaviorally, suggesting an improvement in their ability to perform the task. Closure phenomena have been shown to involve a distributed network of cortical regions, notably the lateral occipital complex (LOC) of the ventral visual stream, dorsal visual stream (DS), hippocampal formation (HIPP) and the prefrontal cortex (PFC). We have previously demonstrated the failure of closure processes in schizophrenia and shown that the dysregulation in the sensory information transmitted to the prefrontal cortex plays a critical role in this failure. Here, using a multimodal imaging approach in patients, combining event related electrophysiological recordings (ERP) and functional magnetic resonance imaging (fMRI), we characterize the spatiotemporal dynamics of priming in perceptual closure. Using directed functional connectivity measures we demonstrate that priming modifies the network-level interactions between the nodes of closure processing in a manner that is functionally advantageous to patients resulting in the mitigation of their deficit in perceptual closure. Frontiers Media S.A. 2020-11-23 /pmc/articles/PMC7719812/ /pubmed/33329086 http://dx.doi.org/10.3389/fpsyt.2020.547189 Text en Copyright © 2020 Sehatpour, Bassir Nia, Adair, Wang, DeBaun, Silipo, Martinez and Javitt. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Sehatpour, Pejman
Bassir Nia, Anahita
Adair, Devin
Wang, Zhishun
DeBaun, Heloise M.
Silipo, Gail
Martinez, Antigona
Javitt, Daniel C.
Multimodal Computational Modeling of Visual Object Recognition Deficits but Intact Repetition Priming in Schizophrenia
title Multimodal Computational Modeling of Visual Object Recognition Deficits but Intact Repetition Priming in Schizophrenia
title_full Multimodal Computational Modeling of Visual Object Recognition Deficits but Intact Repetition Priming in Schizophrenia
title_fullStr Multimodal Computational Modeling of Visual Object Recognition Deficits but Intact Repetition Priming in Schizophrenia
title_full_unstemmed Multimodal Computational Modeling of Visual Object Recognition Deficits but Intact Repetition Priming in Schizophrenia
title_short Multimodal Computational Modeling of Visual Object Recognition Deficits but Intact Repetition Priming in Schizophrenia
title_sort multimodal computational modeling of visual object recognition deficits but intact repetition priming in schizophrenia
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719812/
https://www.ncbi.nlm.nih.gov/pubmed/33329086
http://dx.doi.org/10.3389/fpsyt.2020.547189
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