HDAC6 Inhibition Alleviates CLL-Induced T-Cell Dysfunction and Enhances Immune Checkpoint Blockade Efficacy in the Eμ-TCL1 Model

Development of chronic lymphocytic leukemia (CLL) is associated with severe immune dysfunction. T-cell exhaustion, immune checkpoint upregulation, and increase of regulatory T cells contribute to an immunosuppressive tumor microenvironment. As a result, CLL patients are severely susceptible to infec...

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Detalles Bibliográficos
Autores principales: Maharaj, Kamira, Powers, John J., Mediavilla-Varela, Melanie, Achille, Alex, Gamal, Wael, Quayle, Steven, Jones, Simon S., Sahakian, Eva, Pinilla-Ibarz, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719839/
https://www.ncbi.nlm.nih.gov/pubmed/33329575
http://dx.doi.org/10.3389/fimmu.2020.590072

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