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Application of Bacillus subtilis as a live vaccine vector: A review

Bacillus subtilis is widely used as a probiotic in various fields as it regulates intestinal flora, improves animal growth performance, enhances body immunity, has short fermentation cycle, and is economic. With the rapid development of DNA recombination technology, B. subtilis has been used as a po...

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Autores principales: LV, Penghao, SONG, Yanying, LIU, Cong, YU, Lanping, SHANG, Yingli, TANG, Hui, SUN, Shuhong, WANG, Fangkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719876/
https://www.ncbi.nlm.nih.gov/pubmed/33071249
http://dx.doi.org/10.1292/jvms.20-0363
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author LV, Penghao
SONG, Yanying
LIU, Cong
YU, Lanping
SHANG, Yingli
TANG, Hui
SUN, Shuhong
WANG, Fangkun
author_facet LV, Penghao
SONG, Yanying
LIU, Cong
YU, Lanping
SHANG, Yingli
TANG, Hui
SUN, Shuhong
WANG, Fangkun
author_sort LV, Penghao
collection PubMed
description Bacillus subtilis is widely used as a probiotic in various fields as it regulates intestinal flora, improves animal growth performance, enhances body immunity, has short fermentation cycle, and is economic. With the rapid development of DNA recombination technology, B. subtilis has been used as a potential vaccine expression vector for the treatment and prevention of various diseases caused by bacteria, viruses, and parasites as it can effectively trigger an immune response in the body. In this review, we refer to previous literature and provide a comprehensive analysis and overview of the feasibility of using B. subtilis as a vaccine expression vector, with an aim to provide a valuable reference for the establishment of efficient vaccines.
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spelling pubmed-77198762020-12-09 Application of Bacillus subtilis as a live vaccine vector: A review LV, Penghao SONG, Yanying LIU, Cong YU, Lanping SHANG, Yingli TANG, Hui SUN, Shuhong WANG, Fangkun J Vet Med Sci Immunology Bacillus subtilis is widely used as a probiotic in various fields as it regulates intestinal flora, improves animal growth performance, enhances body immunity, has short fermentation cycle, and is economic. With the rapid development of DNA recombination technology, B. subtilis has been used as a potential vaccine expression vector for the treatment and prevention of various diseases caused by bacteria, viruses, and parasites as it can effectively trigger an immune response in the body. In this review, we refer to previous literature and provide a comprehensive analysis and overview of the feasibility of using B. subtilis as a vaccine expression vector, with an aim to provide a valuable reference for the establishment of efficient vaccines. The Japanese Society of Veterinary Science 2020-10-16 2020-11 /pmc/articles/PMC7719876/ /pubmed/33071249 http://dx.doi.org/10.1292/jvms.20-0363 Text en ©2020 The Japanese Society of Veterinary Science This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Immunology
LV, Penghao
SONG, Yanying
LIU, Cong
YU, Lanping
SHANG, Yingli
TANG, Hui
SUN, Shuhong
WANG, Fangkun
Application of Bacillus subtilis as a live vaccine vector: A review
title Application of Bacillus subtilis as a live vaccine vector: A review
title_full Application of Bacillus subtilis as a live vaccine vector: A review
title_fullStr Application of Bacillus subtilis as a live vaccine vector: A review
title_full_unstemmed Application of Bacillus subtilis as a live vaccine vector: A review
title_short Application of Bacillus subtilis as a live vaccine vector: A review
title_sort application of bacillus subtilis as a live vaccine vector: a review
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7719876/
https://www.ncbi.nlm.nih.gov/pubmed/33071249
http://dx.doi.org/10.1292/jvms.20-0363
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