Allosteric inhibition explained through conformational ensembles sampling distinct “mixed” states

Allosteric modulation provides an effective avenue for selective and potent enzyme inhibition. Here, we summarize and critically discuss recent advances on the mechanisms of allosteric partial agonists for three representative signalling enzymes activated by cyclic nucleotides: the cAMP-dependent pr...

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Detalles Bibliográficos
Autores principales: Byun, Jung Ah, VanSchouwen, Bryan, Akimoto, Madoka, Melacini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720024/
https://www.ncbi.nlm.nih.gov/pubmed/33335680
http://dx.doi.org/10.1016/j.csbj.2020.10.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720024/
https://www.ncbi.nlm.nih.gov/pubmed/33335680
http://dx.doi.org/10.1016/j.csbj.2020.10.026

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