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Confinement Strategies in a Simple SIR Model

We propose a simple deterministic, differential equation-based, SIR model in order to investigate the impact of various confinement strategies on a most virulent epidemic. Our approach is motivated by the current COVID-19 pandemic. The main hypothesis is the existence of two populations of susceptib...

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Autores principales: Nakamura, Gilberto, Grammaticos, Basil, Badoual, Mathilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720040/
http://dx.doi.org/10.1134/S1560354720060015
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author Nakamura, Gilberto
Grammaticos, Basil
Badoual, Mathilde
author_facet Nakamura, Gilberto
Grammaticos, Basil
Badoual, Mathilde
author_sort Nakamura, Gilberto
collection PubMed
description We propose a simple deterministic, differential equation-based, SIR model in order to investigate the impact of various confinement strategies on a most virulent epidemic. Our approach is motivated by the current COVID-19 pandemic. The main hypothesis is the existence of two populations of susceptible persons, one which obeys confinement and for which the infection rate does not exceed 1, and a population which, being non confined for various imperatives, can be substantially more infective. The model, initially formulated as a differential system, is discretised following a specific procedure, the discrete system serving as an integrator for the differential one. Our model is calibrated so as to correspond to what is observed in the COVID-19 epidemic, for the period from February 19 to April 16. Several conclusions can be reached, despite the very simple structure of our model. First, it is not possible to pinpoint the genesis of the epidemic by just analysing data from when the epidemic is in full swing. It may well turn out that the epidemic has reached a sizeable part of the world months before it became noticeable. Concerning the confinement scenarios, a universal feature of all our simulations is that relaxing the lockdown constraints leads to a rekindling of the epidemic. Thus, we sought the conditions for the second epidemic peak to be lower than the first one. This is possible in all the scenarios considered (abrupt or gradualexit, the latter having linear and stepwise profiles), but typically a gradual exit can start earlier than an abrupt one. However, by the time the gradual exit is complete, the overall confinement times are not too different. From our results, the most promising strategy is that of a stepwise exit. Its implementation could be quite feasible, with the major part of the population (perhaps, minus the fragile groups) exiting simultaneously, but obeying rigorous distancing constraints.
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spelling pubmed-77200402020-12-07 Confinement Strategies in a Simple SIR Model Nakamura, Gilberto Grammaticos, Basil Badoual, Mathilde Regul. Chaot. Dyn. Article We propose a simple deterministic, differential equation-based, SIR model in order to investigate the impact of various confinement strategies on a most virulent epidemic. Our approach is motivated by the current COVID-19 pandemic. The main hypothesis is the existence of two populations of susceptible persons, one which obeys confinement and for which the infection rate does not exceed 1, and a population which, being non confined for various imperatives, can be substantially more infective. The model, initially formulated as a differential system, is discretised following a specific procedure, the discrete system serving as an integrator for the differential one. Our model is calibrated so as to correspond to what is observed in the COVID-19 epidemic, for the period from February 19 to April 16. Several conclusions can be reached, despite the very simple structure of our model. First, it is not possible to pinpoint the genesis of the epidemic by just analysing data from when the epidemic is in full swing. It may well turn out that the epidemic has reached a sizeable part of the world months before it became noticeable. Concerning the confinement scenarios, a universal feature of all our simulations is that relaxing the lockdown constraints leads to a rekindling of the epidemic. Thus, we sought the conditions for the second epidemic peak to be lower than the first one. This is possible in all the scenarios considered (abrupt or gradualexit, the latter having linear and stepwise profiles), but typically a gradual exit can start earlier than an abrupt one. However, by the time the gradual exit is complete, the overall confinement times are not too different. From our results, the most promising strategy is that of a stepwise exit. Its implementation could be quite feasible, with the major part of the population (perhaps, minus the fragile groups) exiting simultaneously, but obeying rigorous distancing constraints. Pleiades Publishing 2020-12-21 2020 /pmc/articles/PMC7720040/ http://dx.doi.org/10.1134/S1560354720060015 Text en © Pleiades Publishing, Ltd. 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Nakamura, Gilberto
Grammaticos, Basil
Badoual, Mathilde
Confinement Strategies in a Simple SIR Model
title Confinement Strategies in a Simple SIR Model
title_full Confinement Strategies in a Simple SIR Model
title_fullStr Confinement Strategies in a Simple SIR Model
title_full_unstemmed Confinement Strategies in a Simple SIR Model
title_short Confinement Strategies in a Simple SIR Model
title_sort confinement strategies in a simple sir model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720040/
http://dx.doi.org/10.1134/S1560354720060015
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