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A retrospective analysis of eosinophilia as a predictive marker of response and toxicity to cancer immunotherapy
AIM: To investigate eosinophilia as a potential on-treatment biomarker for patients receiving cancer immunotherapy. MATERIALS & METHODS: We evaluated the association between eosinophilia and treatment response and toxicity in a retrospective cohort of patients receiving cancer immunotherapy. RES...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Future Science Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720365/ https://www.ncbi.nlm.nih.gov/pubmed/33312694 http://dx.doi.org/10.2144/fsoa-2020-0070 |
Sumario: | AIM: To investigate eosinophilia as a potential on-treatment biomarker for patients receiving cancer immunotherapy. MATERIALS & METHODS: We evaluated the association between eosinophilia and treatment response and toxicity in a retrospective cohort of patients receiving cancer immunotherapy. RESULTS: The study involved 146 patients. Eosinophilia developed in 22%. Patients who developed eosinophilia were more likely to achieve disease control (p = 0.009), with every 0.1 × 10(9)/l rise in eosinophil count, while receiving treatment was associated with a 28% relative increased chance achieving disease control. Although there was a trend toward improved survival, there was no significant association between eosinophilia and improved overall survival (p = 0.136). Patients with eosinophilia were more likely to develop toxicity (p = 0.042). CONCLUSION: Eosinophilia is a potentially useful biomarker warranting further prospective clinical investigation. |
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