The value of anti-epileptic therapy as a prophylactic factor for seizures in the management of moderate traumatic brain injury

AIM: The value of anti-epileptic therapy in the prophylaxis of post-traumatic seizures. PATIENTS & METHODS: All patients received a standard anti-epileptic drug (AED) and were divided into two groups: Group A -with early AED and Group B -with late AED. RESULTS: Patients (871/1062) met the inclus...

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Detalles Bibliográficos
Autores principales: Faropoulos, Konstantinos, Makris, Demosthenes, Fotakopoulos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720367/
https://www.ncbi.nlm.nih.gov/pubmed/33312700
http://dx.doi.org/10.2144/fsoa-2020-0080
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author Faropoulos, Konstantinos
Makris, Demosthenes
Fotakopoulos, George
author_facet Faropoulos, Konstantinos
Makris, Demosthenes
Fotakopoulos, George
author_sort Faropoulos, Konstantinos
collection PubMed
description AIM: The value of anti-epileptic therapy in the prophylaxis of post-traumatic seizures. PATIENTS & METHODS: All patients received a standard anti-epileptic drug (AED) and were divided into two groups: Group A -with early AED and Group B -with late AED. RESULTS: Patients (871/1062) met the inclusion criteria. Multivariate analysis demonstrated that computer tomography findings, headache and prior history of brain head injury were independent risk factors of seizures. Only late post-traumatic seizures (LPTS) was significantly associated with AED (p < 0.05). CONCLUSION: Early treatment with AED seems to not affect the incidence of lPTS. In addition, an AED with a mean time of initiation of 7.5 days from the moderate traumatic brain injury occurrence could reduce the lPTS incidence.
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spelling pubmed-77203672020-12-11 The value of anti-epileptic therapy as a prophylactic factor for seizures in the management of moderate traumatic brain injury Faropoulos, Konstantinos Makris, Demosthenes Fotakopoulos, George Future Sci OA Short Communication AIM: The value of anti-epileptic therapy in the prophylaxis of post-traumatic seizures. PATIENTS & METHODS: All patients received a standard anti-epileptic drug (AED) and were divided into two groups: Group A -with early AED and Group B -with late AED. RESULTS: Patients (871/1062) met the inclusion criteria. Multivariate analysis demonstrated that computer tomography findings, headache and prior history of brain head injury were independent risk factors of seizures. Only late post-traumatic seizures (LPTS) was significantly associated with AED (p < 0.05). CONCLUSION: Early treatment with AED seems to not affect the incidence of lPTS. In addition, an AED with a mean time of initiation of 7.5 days from the moderate traumatic brain injury occurrence could reduce the lPTS incidence. Future Science Ltd 2020-08-28 /pmc/articles/PMC7720367/ /pubmed/33312700 http://dx.doi.org/10.2144/fsoa-2020-0080 Text en © 2020 George Fotakopoulos This work is licensed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/)
spellingShingle Short Communication
Faropoulos, Konstantinos
Makris, Demosthenes
Fotakopoulos, George
The value of anti-epileptic therapy as a prophylactic factor for seizures in the management of moderate traumatic brain injury
title The value of anti-epileptic therapy as a prophylactic factor for seizures in the management of moderate traumatic brain injury
title_full The value of anti-epileptic therapy as a prophylactic factor for seizures in the management of moderate traumatic brain injury
title_fullStr The value of anti-epileptic therapy as a prophylactic factor for seizures in the management of moderate traumatic brain injury
title_full_unstemmed The value of anti-epileptic therapy as a prophylactic factor for seizures in the management of moderate traumatic brain injury
title_short The value of anti-epileptic therapy as a prophylactic factor for seizures in the management of moderate traumatic brain injury
title_sort value of anti-epileptic therapy as a prophylactic factor for seizures in the management of moderate traumatic brain injury
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720367/
https://www.ncbi.nlm.nih.gov/pubmed/33312700
http://dx.doi.org/10.2144/fsoa-2020-0080
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