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Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease
Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ) aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer’s disease (AD) through prion-like mechanisms. In this study, we evaluated whether brain amyloidosis could be accelerated by blood inf...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720397/ https://www.ncbi.nlm.nih.gov/pubmed/33287898 http://dx.doi.org/10.1186/s40478-020-01087-1 |
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author | Morales, Rodrigo Duran-Aniotz, Claudia Bravo-Alegria, Javiera Estrada, Lisbell D. Shahnawaz, Mohammad Hu, Ping-Ping Kramm, Carlos Morales-Scheihing, Diego Urayama, Akihiko Soto, Claudio |
author_facet | Morales, Rodrigo Duran-Aniotz, Claudia Bravo-Alegria, Javiera Estrada, Lisbell D. Shahnawaz, Mohammad Hu, Ping-Ping Kramm, Carlos Morales-Scheihing, Diego Urayama, Akihiko Soto, Claudio |
author_sort | Morales, Rodrigo |
collection | PubMed |
description | Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ) aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer’s disease (AD) through prion-like mechanisms. In this study, we evaluated whether brain amyloidosis could be accelerated by blood infusions, procedures that have been shown to transmit prion diseases in animals and humans. Young transgenic mice infused with whole blood or plasma from old animals with extensive Aβ deposition in their brains developed significantly higher levels brain amyloidosis and neuroinflammation compared to untreated animals or mice infused with wild type blood. Similarly, intra-venous injection of purified Aβ aggregates accelerated amyloid pathology, supporting the concept that Aβ seeds present in blood can reach the brain to promote neuropathological alterations in the brain of treated animals. However, an amyloid-enhancing effect of other factors present in the blood of donors cannot be discarded. Our results may help to understand the role of peripheral (amyloid-dependent or -independent) factors implicated in the development of AD and uncover new strategies for disease intervention. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40478-020-01087-1) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7720397 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77203972020-12-07 Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease Morales, Rodrigo Duran-Aniotz, Claudia Bravo-Alegria, Javiera Estrada, Lisbell D. Shahnawaz, Mohammad Hu, Ping-Ping Kramm, Carlos Morales-Scheihing, Diego Urayama, Akihiko Soto, Claudio Acta Neuropathol Commun Research Previous studies showed that injection of tissue extracts containing amyloid-β (Aβ) aggregates accelerate amyloid deposition in the brain of mouse models of Alzheimer’s disease (AD) through prion-like mechanisms. In this study, we evaluated whether brain amyloidosis could be accelerated by blood infusions, procedures that have been shown to transmit prion diseases in animals and humans. Young transgenic mice infused with whole blood or plasma from old animals with extensive Aβ deposition in their brains developed significantly higher levels brain amyloidosis and neuroinflammation compared to untreated animals or mice infused with wild type blood. Similarly, intra-venous injection of purified Aβ aggregates accelerated amyloid pathology, supporting the concept that Aβ seeds present in blood can reach the brain to promote neuropathological alterations in the brain of treated animals. However, an amyloid-enhancing effect of other factors present in the blood of donors cannot be discarded. Our results may help to understand the role of peripheral (amyloid-dependent or -independent) factors implicated in the development of AD and uncover new strategies for disease intervention. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40478-020-01087-1) contains supplementary material, which is available to authorized users. BioMed Central 2020-12-07 /pmc/articles/PMC7720397/ /pubmed/33287898 http://dx.doi.org/10.1186/s40478-020-01087-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Morales, Rodrigo Duran-Aniotz, Claudia Bravo-Alegria, Javiera Estrada, Lisbell D. Shahnawaz, Mohammad Hu, Ping-Ping Kramm, Carlos Morales-Scheihing, Diego Urayama, Akihiko Soto, Claudio Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease |
title | Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease |
title_full | Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease |
title_fullStr | Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease |
title_full_unstemmed | Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease |
title_short | Infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of Alzheimer’s disease |
title_sort | infusion of blood from mice displaying cerebral amyloidosis accelerates amyloid pathology in animal models of alzheimer’s disease |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720397/ https://www.ncbi.nlm.nih.gov/pubmed/33287898 http://dx.doi.org/10.1186/s40478-020-01087-1 |
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