Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia

Hereditary spastic paraplegias (HSPs) are caused by a length-dependent axonopathy of long corticospinal neurons, but how axons of these cortical projection neurons (PNs) degenerate remains elusive. We generated isogenic human pluripotent stem cell (hPSC) lines for two ATL1 missense mutations associa...

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Detalles Bibliográficos
Autores principales: Mou, Yongchao, Dong, Yi, Chen, Zhenyu, Denton, Kyle R., Duff, Michael O., Blackstone, Craig, Zhang, Su-Chun, Li, Xue-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720406/
https://www.ncbi.nlm.nih.gov/pubmed/33287888
http://dx.doi.org/10.1186/s40478-020-01088-0

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