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Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study
BACKGROUND: Sleep disturbances are prevalent among older adults and are associated with various individual diseases. The aim of this study was to investigate whether sleep disturbances are associated with the speed of multimorbidity development among older adults. METHODS: Data were gathered from th...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720467/ https://www.ncbi.nlm.nih.gov/pubmed/33280611 http://dx.doi.org/10.1186/s12916-020-01846-w |
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author | Sindi, Shireen Pérez, Laura Monica Vetrano, Davide L. Triolo, Federico Kåreholt, Ingemar Sjöberg, Linnea Darin-Mattsson, Alexander Kivipelto, Miia Inzitari, Marco Calderón-Larrañaga, Amaia |
author_facet | Sindi, Shireen Pérez, Laura Monica Vetrano, Davide L. Triolo, Federico Kåreholt, Ingemar Sjöberg, Linnea Darin-Mattsson, Alexander Kivipelto, Miia Inzitari, Marco Calderón-Larrañaga, Amaia |
author_sort | Sindi, Shireen |
collection | PubMed |
description | BACKGROUND: Sleep disturbances are prevalent among older adults and are associated with various individual diseases. The aim of this study was to investigate whether sleep disturbances are associated with the speed of multimorbidity development among older adults. METHODS: Data were gathered from the Swedish National study of Aging and Care in Kungsholmen (SNAC-K), an ongoing population-based study of subjects aged 60+ (N = 3363). The study included a subsample (n = 1189) without multimorbidity at baseline (< 2 chronic diseases). Baseline sleep disturbances were derived from the Comprehensive Psychiatric Rating Scale and categorized as none, mild, and moderate–severe. The number of chronic conditions throughout the 9-year follow-up was obtained from clinical examinations. Linear mixed models were used to study the association between sleep disturbances and the speed of chronic disease accumulation, adjusting for sex, age, education, physical activity, smoking, alcohol consumption, depression, pain, and psychotropic drug use. We repeated the analyses including only cardiovascular, neuropsychiatric, or musculoskeletal diseases as the outcome. RESULTS: Moderate–severe sleep disturbances were associated with a higher speed of chronic disease accumulation (ß/year = 0.142, p = 0.008), regardless of potential confounders. Significant positive associations were also found between moderate–severe sleep disturbances and neuropsychiatric (ß/year = 0.041, p = 0.016) and musculoskeletal (ß/year = 0.038, p = 0.025) disease accumulation, but not with cardiovascular diseases. Results remained stable when participants with baseline dementia, cognitive impairment, or depression were excluded. CONCLUSION: The finding that sleep disturbances are associated with faster chronic disease accumulation points towards the importance of early detection and treatment of sleep disturbances as a possible strategy to reduce chronic multimorbidity among older adults. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-020-01846-w. |
format | Online Article Text |
id | pubmed-7720467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-77204672020-12-07 Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study Sindi, Shireen Pérez, Laura Monica Vetrano, Davide L. Triolo, Federico Kåreholt, Ingemar Sjöberg, Linnea Darin-Mattsson, Alexander Kivipelto, Miia Inzitari, Marco Calderón-Larrañaga, Amaia BMC Med Research Article BACKGROUND: Sleep disturbances are prevalent among older adults and are associated with various individual diseases. The aim of this study was to investigate whether sleep disturbances are associated with the speed of multimorbidity development among older adults. METHODS: Data were gathered from the Swedish National study of Aging and Care in Kungsholmen (SNAC-K), an ongoing population-based study of subjects aged 60+ (N = 3363). The study included a subsample (n = 1189) without multimorbidity at baseline (< 2 chronic diseases). Baseline sleep disturbances were derived from the Comprehensive Psychiatric Rating Scale and categorized as none, mild, and moderate–severe. The number of chronic conditions throughout the 9-year follow-up was obtained from clinical examinations. Linear mixed models were used to study the association between sleep disturbances and the speed of chronic disease accumulation, adjusting for sex, age, education, physical activity, smoking, alcohol consumption, depression, pain, and psychotropic drug use. We repeated the analyses including only cardiovascular, neuropsychiatric, or musculoskeletal diseases as the outcome. RESULTS: Moderate–severe sleep disturbances were associated with a higher speed of chronic disease accumulation (ß/year = 0.142, p = 0.008), regardless of potential confounders. Significant positive associations were also found between moderate–severe sleep disturbances and neuropsychiatric (ß/year = 0.041, p = 0.016) and musculoskeletal (ß/year = 0.038, p = 0.025) disease accumulation, but not with cardiovascular diseases. Results remained stable when participants with baseline dementia, cognitive impairment, or depression were excluded. CONCLUSION: The finding that sleep disturbances are associated with faster chronic disease accumulation points towards the importance of early detection and treatment of sleep disturbances as a possible strategy to reduce chronic multimorbidity among older adults. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12916-020-01846-w. BioMed Central 2020-12-07 /pmc/articles/PMC7720467/ /pubmed/33280611 http://dx.doi.org/10.1186/s12916-020-01846-w Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Sindi, Shireen Pérez, Laura Monica Vetrano, Davide L. Triolo, Federico Kåreholt, Ingemar Sjöberg, Linnea Darin-Mattsson, Alexander Kivipelto, Miia Inzitari, Marco Calderón-Larrañaga, Amaia Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study |
title | Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study |
title_full | Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study |
title_fullStr | Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study |
title_full_unstemmed | Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study |
title_short | Sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study |
title_sort | sleep disturbances and the speed of multimorbidity development in old age: results from a longitudinal population-based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720467/ https://www.ncbi.nlm.nih.gov/pubmed/33280611 http://dx.doi.org/10.1186/s12916-020-01846-w |
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