Cargando…

Alternative splicing in endothelial cells: novel therapeutic opportunities in cancer angiogenesis

Alternative splicing (AS) is a pervasive molecular process generating multiple protein isoforms, from a single gene. It plays fundamental roles during development, differentiation and maintenance of tissue homeostasis, while aberrant AS is considered a hallmark of multiple diseases, including cancer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Di Matteo, Anna, Belloni, Elisa, Pradella, Davide, Cappelletto, Ambra, Volf, Nina, Zacchigna, Serena, Ghigna, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720527/ https://www.ncbi.nlm.nih.gov/pubmed/33287867 http://dx.doi.org/10.1186/s13046-020-01753-1

Ejemplares similares

Gene Expression Profiles Controlled by the Alternative Splicing Factor Nova2 in Endothelial Cells
por: Belloni, Elisa, et al.
Publicado: (2019)

A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis
por: Pradella, Davide, et al.
Publicado: (2021)

EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
por: Pradella, Davide, et al.
Publicado: (2017)

Alternative Splicing Changes Promoted by NOVA2 Upregulation in Endothelial Cells and Relevance for Gastric Cancer
por: Di Matteo, Anna, et al.
Publicado: (2023)

Cardiac revascularization: state of the art and perspectives
por: Cappelletto, Ambra, et al.
Publicado: (2019)

Global Alternative Splicing Defects in Human Breast Cancer Cells
por: Oh, Jagyeong, et al.
Publicado: (2021)

Genetic lineage tracing reveals poor angiogenic potential of cardiac endothelial cells
por: Kocijan, Tea, et al.
Publicado: (2020)

Widespread Alternative Splicing Changes in Metastatic Breast Cancer Cells
por: Oh, Jagyeong, et al.
Publicado: (2021)

SAM68: Signal Transduction and RNA Metabolism in Human Cancer
por: Frisone, Paola, et al.
Publicado: (2015)

Diversification of the muscle proteome through alternative splicing
por: Nakka, Kiran, et al.
Publicado: (2018)

Alternative Splicing and Tumor Progression
por: Ghigna, Claudia, et al.
Publicado: (2008)

The alternative splicing factor Nova2 regulates vascular development and lumen formation
por: Giampietro, Costanza, et al.
Publicado: (2015)

Alternative Splicing: Role in Cancer Development and Progression
por: Sette, Claudio, et al.
Publicado: (2013)

Alternative Splicing: Recent Insights into Mechanisms and Functional Roles
por: Ghigna, Claudia, et al.
Publicado: (2020)

Oncogenic Alternative Splicing Switches: Role in Cancer Progression and Prospects for Therapy
por: Bonomi, Serena, et al.
Publicado: (2013)

Regulation of the Ras-MAPK and PI3K-mTOR Signalling Pathways by Alternative Splicing in Cancer
por: Siegfried, Zahava, et al.
Publicado: (2013)

A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing
por: Angiolini, Francesca, et al.
Publicado: (2019)

Alternative Splicing in Angiogenesis
por: Bowler, Elizabeth, et al.
Publicado: (2019)

Opposite Roles of Tra2β and SRSF9 in the v10 Exon Splicing of CD44
por: Oh, Jagyeong, et al.
Publicado: (2020)

Alternative Splicing Events and Their Clinical Significance in Colorectal Cancer: Targeted Therapeutic Opportunities
por: Manabile, Mosebo Armstrong, et al.
Publicado: (2023)

Angiogenesis and Its Therapeutic Opportunities
por: Yoo, So Young, et al.
Publicado: (2013)

Relative strength of 5’ splice-site strength defines functions of SRSF2 and SRSF6 in alternative splicing of Bcl-x pre-mRNA
por: Choi, Namjeong, et al.
Publicado: (2021)

SRSF9 Regulates Cassette Exon Splicing of Caspase-2 by Interacting with Its Downstream Exon
por: Ha, Jiyeon, et al.
Publicado: (2021)

Sam68 regulates EMT through alternative splicing–activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene
por: Valacca, Cristina, et al.
Publicado: (2010)

HnRNP A1 controls a splicing regulatory circuit promoting mesenchymal-to-epithelial transition
por: Bonomi, Serena, et al.
Publicado: (2013)

Hypoxia-Induced Alternative Splicing in Endothelial Cells
por: Weigand, Julia E., et al.
Publicado: (2012)

Alternative Splicing: Expanding the Landscape of Cancer Biomarkers and Therapeutics
por: Bessa, Cláudia, et al.
Publicado: (2020)

Aberrant RNA splicing and therapeutic opportunities in cancers
por: Yamauchi, Hirofumi, et al.
Publicado: (2021)

Endothelial cell–cardiomyocyte crosstalk in heart development and disease
por: Colliva, Andrea, et al.
Publicado: (2019)

Abnormalities in alternative splicing of angiogenesis-related genes and their role in HIV-related cancers
por: Mthembu, Nonkululeko N, et al.
Publicado: (2017)

SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet procoagulant activity
por: Cappelletto, Ambra, et al.
Publicado: (2023)

Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome
por: Cherry, Sara, et al.
Publicado: (2020)

Extracellular Matrix-Based Approaches in Cardiac Regeneration: Challenges and Opportunities
por: Vu, Thi Van Anh, et al.
Publicado: (2022)

Therapeutic Applications of Targeted Alternative Splicing to Cancer Treatment
por: Lin, Jung-Chun
Publicado: (2017)

From bedside to the bench: patient-specific hiPSC-EC models uncover endothelial dysfunction in genetic cardiomyopathies
por: Rabino, Martina, et al.
Publicado: (2023)

The diversity of endothelial cells: a challenge for therapeutic angiogenesis
por: Conway, Edward M, et al.
Publicado: (2004)

Alternative Splice in Alternative Lice
por: Tovar-Corona, Jaime M., et al.
Publicado: (2015)

Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms: A NOVEL THERAPEUTIC STRATEGY FOR ANGIOGENESIS
por: Nowak, Dawid G., et al.
Publicado: (2010)

FOXA1 regulates alternative splicing in prostate cancer
por: Del Giudice, Marco, et al.
Publicado: (2022)

Alternative Splicing of the Angiogenesis Associated Extra-Domain B of Fibronectin Regulates the Accessibility of the B-C Loop of the Type III Repeat 8
por: Ventura, Elisa, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_ob1kgtikmhce7qe60bdua2rtgr