Emergence of spatio-temporal variations in chemotherapeutic drug efficacy: in-vitro and in-Silico 3D tumour spheroid studies

BACKGROUND: The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. We explore the emergence of spatially preferential drug efficacy resulting from...

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Detalles Bibliográficos
Autores principales: Sheraton, M. V., Chiew, G. G. Y., Melnikov, V., Tan, E. Y., Luo, K. Q., Verma, N., Sloot, P. M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720561/
https://www.ncbi.nlm.nih.gov/pubmed/33287759
http://dx.doi.org/10.1186/s12885-020-07677-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720561/
https://www.ncbi.nlm.nih.gov/pubmed/33287759
http://dx.doi.org/10.1186/s12885-020-07677-5

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