Cargando…
P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations
Schizophrenia is a complex disorder about which much is still unknown. Potential treatments, such as transcranial magnetic stimulation (TMS), have not been exploited, in part because of the variability in behavioral response. This can be overcome with the use of response biomarkers. It has been howe...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720634/ https://www.ncbi.nlm.nih.gov/pubmed/33328850 http://dx.doi.org/10.3389/fnins.2020.575538 |
_version_ | 1783619888697311232 |
---|---|
author | Aubonnet, Romain Banea, Ovidiu C. Sirica, Roberta Wassermann, Eric M. Yassine, Sahar Jacob, Deborah Magnúsdóttir, Brynja Björk Haraldsson, Magnús Stefansson, Sigurjon B. Jónasson, Viktor D. Ívarsson, Eysteinn Jónasson, Aron D. Hassan, Mahmoud Gargiulo, Paolo |
author_facet | Aubonnet, Romain Banea, Ovidiu C. Sirica, Roberta Wassermann, Eric M. Yassine, Sahar Jacob, Deborah Magnúsdóttir, Brynja Björk Haraldsson, Magnús Stefansson, Sigurjon B. Jónasson, Viktor D. Ívarsson, Eysteinn Jónasson, Aron D. Hassan, Mahmoud Gargiulo, Paolo |
author_sort | Aubonnet, Romain |
collection | PubMed |
description | Schizophrenia is a complex disorder about which much is still unknown. Potential treatments, such as transcranial magnetic stimulation (TMS), have not been exploited, in part because of the variability in behavioral response. This can be overcome with the use of response biomarkers. It has been however shown that repetitive transcranial magnetic stimulation (rTMS) can the relieve positive and negative symptoms of schizophrenia, particularly auditory verbal hallucinations (AVH). This exploratory work aims to establish a quantitative methodological tool, based on high-density electroencephalogram (HD-EEG) data analysis, to assess the effect of rTMS on patients with schizophrenia and AVH. Ten schizophrenia patients with drug-resistant AVH were divided into two groups: the treatment group (TG) received 1 Hz rTMS treatment during 10 daily sessions (900 pulses/session) over the left T3-P3 International 10-20 location. The control group (CG) received rTMS treatment over the Cz (vertex) EEG location. We used the P300 oddball auditory paradigm, known for its reduced amplitude in schizophrenia with AVH, and recorded high-density electroencephalography (HD-EEG, 256 channels), twice for each patient: pre-rTMS and 1 week post-rTMS treatment. The use of HD-EEG enabled the analysis of the data in the time domain, but also in the frequency and source-space connectivity domains. The HD-EEG data were linked with the clinical outcome derived from the auditory hallucinations subscale (AHS) of the Psychotic Symptom Rating Scale (PSYRATS), the Quality of Life Scale (QoLS), and the Depression, Anxiety and Stress Scale (DASS). The general results show a variability between subjects, independent of the group they belong to. The time domain showed a higher N1-P3 amplitude post-rTMS, the frequency domain a higher power spectral density (PSD) in the alpha and beta bands, and the connectivity analysis revealed a higher brain network integration (quantified using the participation coefficient) in the beta band. Despite the small number of subjects and the high variability of the results, this work shows a robust data analysis and an interplay between morphology, spectral, and connectivity data. The identification of a trend post-rTMS for each domain in our results is a first step toward the definition of quantitative neurophysiological parameters to assess rTMS treatment. |
format | Online Article Text |
id | pubmed-7720634 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77206342020-12-15 P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations Aubonnet, Romain Banea, Ovidiu C. Sirica, Roberta Wassermann, Eric M. Yassine, Sahar Jacob, Deborah Magnúsdóttir, Brynja Björk Haraldsson, Magnús Stefansson, Sigurjon B. Jónasson, Viktor D. Ívarsson, Eysteinn Jónasson, Aron D. Hassan, Mahmoud Gargiulo, Paolo Front Neurosci Neuroscience Schizophrenia is a complex disorder about which much is still unknown. Potential treatments, such as transcranial magnetic stimulation (TMS), have not been exploited, in part because of the variability in behavioral response. This can be overcome with the use of response biomarkers. It has been however shown that repetitive transcranial magnetic stimulation (rTMS) can the relieve positive and negative symptoms of schizophrenia, particularly auditory verbal hallucinations (AVH). This exploratory work aims to establish a quantitative methodological tool, based on high-density electroencephalogram (HD-EEG) data analysis, to assess the effect of rTMS on patients with schizophrenia and AVH. Ten schizophrenia patients with drug-resistant AVH were divided into two groups: the treatment group (TG) received 1 Hz rTMS treatment during 10 daily sessions (900 pulses/session) over the left T3-P3 International 10-20 location. The control group (CG) received rTMS treatment over the Cz (vertex) EEG location. We used the P300 oddball auditory paradigm, known for its reduced amplitude in schizophrenia with AVH, and recorded high-density electroencephalography (HD-EEG, 256 channels), twice for each patient: pre-rTMS and 1 week post-rTMS treatment. The use of HD-EEG enabled the analysis of the data in the time domain, but also in the frequency and source-space connectivity domains. The HD-EEG data were linked with the clinical outcome derived from the auditory hallucinations subscale (AHS) of the Psychotic Symptom Rating Scale (PSYRATS), the Quality of Life Scale (QoLS), and the Depression, Anxiety and Stress Scale (DASS). The general results show a variability between subjects, independent of the group they belong to. The time domain showed a higher N1-P3 amplitude post-rTMS, the frequency domain a higher power spectral density (PSD) in the alpha and beta bands, and the connectivity analysis revealed a higher brain network integration (quantified using the participation coefficient) in the beta band. Despite the small number of subjects and the high variability of the results, this work shows a robust data analysis and an interplay between morphology, spectral, and connectivity data. The identification of a trend post-rTMS for each domain in our results is a first step toward the definition of quantitative neurophysiological parameters to assess rTMS treatment. Frontiers Media S.A. 2020-11-20 /pmc/articles/PMC7720634/ /pubmed/33328850 http://dx.doi.org/10.3389/fnins.2020.575538 Text en Copyright © 2020 Aubonnet, Banea, Sirica, Wassermann, Yassine, Jacob, Magnúsdóttir, Haraldsson, Stefansson, Jónasson, Ívarsson, Jónasson, Hassan and Gargiulo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Aubonnet, Romain Banea, Ovidiu C. Sirica, Roberta Wassermann, Eric M. Yassine, Sahar Jacob, Deborah Magnúsdóttir, Brynja Björk Haraldsson, Magnús Stefansson, Sigurjon B. Jónasson, Viktor D. Ívarsson, Eysteinn Jónasson, Aron D. Hassan, Mahmoud Gargiulo, Paolo P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations |
title | P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations |
title_full | P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations |
title_fullStr | P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations |
title_full_unstemmed | P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations |
title_short | P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations |
title_sort | p300 analysis using high-density eeg to decipher neural response to rtms in patients with schizophrenia and auditory verbal hallucinations |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720634/ https://www.ncbi.nlm.nih.gov/pubmed/33328850 http://dx.doi.org/10.3389/fnins.2020.575538 |
work_keys_str_mv | AT aubonnetromain p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT baneaovidiuc p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT siricaroberta p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT wassermannericm p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT yassinesahar p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT jacobdeborah p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT magnusdottirbrynjabjork p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT haraldssonmagnus p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT stefanssonsigurjonb p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT jonassonviktord p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT ivarssoneysteinn p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT jonassonarond p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT hassanmahmoud p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations AT gargiulopaolo p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations |