Cargando…

P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations

Schizophrenia is a complex disorder about which much is still unknown. Potential treatments, such as transcranial magnetic stimulation (TMS), have not been exploited, in part because of the variability in behavioral response. This can be overcome with the use of response biomarkers. It has been howe...

Descripción completa

Detalles Bibliográficos
Autores principales: Aubonnet, Romain, Banea, Ovidiu C., Sirica, Roberta, Wassermann, Eric M., Yassine, Sahar, Jacob, Deborah, Magnúsdóttir, Brynja Björk, Haraldsson, Magnús, Stefansson, Sigurjon B., Jónasson, Viktor D., Ívarsson, Eysteinn, Jónasson, Aron D., Hassan, Mahmoud, Gargiulo, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720634/
https://www.ncbi.nlm.nih.gov/pubmed/33328850
http://dx.doi.org/10.3389/fnins.2020.575538
_version_ 1783619888697311232
author Aubonnet, Romain
Banea, Ovidiu C.
Sirica, Roberta
Wassermann, Eric M.
Yassine, Sahar
Jacob, Deborah
Magnúsdóttir, Brynja Björk
Haraldsson, Magnús
Stefansson, Sigurjon B.
Jónasson, Viktor D.
Ívarsson, Eysteinn
Jónasson, Aron D.
Hassan, Mahmoud
Gargiulo, Paolo
author_facet Aubonnet, Romain
Banea, Ovidiu C.
Sirica, Roberta
Wassermann, Eric M.
Yassine, Sahar
Jacob, Deborah
Magnúsdóttir, Brynja Björk
Haraldsson, Magnús
Stefansson, Sigurjon B.
Jónasson, Viktor D.
Ívarsson, Eysteinn
Jónasson, Aron D.
Hassan, Mahmoud
Gargiulo, Paolo
author_sort Aubonnet, Romain
collection PubMed
description Schizophrenia is a complex disorder about which much is still unknown. Potential treatments, such as transcranial magnetic stimulation (TMS), have not been exploited, in part because of the variability in behavioral response. This can be overcome with the use of response biomarkers. It has been however shown that repetitive transcranial magnetic stimulation (rTMS) can the relieve positive and negative symptoms of schizophrenia, particularly auditory verbal hallucinations (AVH). This exploratory work aims to establish a quantitative methodological tool, based on high-density electroencephalogram (HD-EEG) data analysis, to assess the effect of rTMS on patients with schizophrenia and AVH. Ten schizophrenia patients with drug-resistant AVH were divided into two groups: the treatment group (TG) received 1 Hz rTMS treatment during 10 daily sessions (900 pulses/session) over the left T3-P3 International 10-20 location. The control group (CG) received rTMS treatment over the Cz (vertex) EEG location. We used the P300 oddball auditory paradigm, known for its reduced amplitude in schizophrenia with AVH, and recorded high-density electroencephalography (HD-EEG, 256 channels), twice for each patient: pre-rTMS and 1 week post-rTMS treatment. The use of HD-EEG enabled the analysis of the data in the time domain, but also in the frequency and source-space connectivity domains. The HD-EEG data were linked with the clinical outcome derived from the auditory hallucinations subscale (AHS) of the Psychotic Symptom Rating Scale (PSYRATS), the Quality of Life Scale (QoLS), and the Depression, Anxiety and Stress Scale (DASS). The general results show a variability between subjects, independent of the group they belong to. The time domain showed a higher N1-P3 amplitude post-rTMS, the frequency domain a higher power spectral density (PSD) in the alpha and beta bands, and the connectivity analysis revealed a higher brain network integration (quantified using the participation coefficient) in the beta band. Despite the small number of subjects and the high variability of the results, this work shows a robust data analysis and an interplay between morphology, spectral, and connectivity data. The identification of a trend post-rTMS for each domain in our results is a first step toward the definition of quantitative neurophysiological parameters to assess rTMS treatment.
format Online
Article
Text
id pubmed-7720634
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-77206342020-12-15 P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations Aubonnet, Romain Banea, Ovidiu C. Sirica, Roberta Wassermann, Eric M. Yassine, Sahar Jacob, Deborah Magnúsdóttir, Brynja Björk Haraldsson, Magnús Stefansson, Sigurjon B. Jónasson, Viktor D. Ívarsson, Eysteinn Jónasson, Aron D. Hassan, Mahmoud Gargiulo, Paolo Front Neurosci Neuroscience Schizophrenia is a complex disorder about which much is still unknown. Potential treatments, such as transcranial magnetic stimulation (TMS), have not been exploited, in part because of the variability in behavioral response. This can be overcome with the use of response biomarkers. It has been however shown that repetitive transcranial magnetic stimulation (rTMS) can the relieve positive and negative symptoms of schizophrenia, particularly auditory verbal hallucinations (AVH). This exploratory work aims to establish a quantitative methodological tool, based on high-density electroencephalogram (HD-EEG) data analysis, to assess the effect of rTMS on patients with schizophrenia and AVH. Ten schizophrenia patients with drug-resistant AVH were divided into two groups: the treatment group (TG) received 1 Hz rTMS treatment during 10 daily sessions (900 pulses/session) over the left T3-P3 International 10-20 location. The control group (CG) received rTMS treatment over the Cz (vertex) EEG location. We used the P300 oddball auditory paradigm, known for its reduced amplitude in schizophrenia with AVH, and recorded high-density electroencephalography (HD-EEG, 256 channels), twice for each patient: pre-rTMS and 1 week post-rTMS treatment. The use of HD-EEG enabled the analysis of the data in the time domain, but also in the frequency and source-space connectivity domains. The HD-EEG data were linked with the clinical outcome derived from the auditory hallucinations subscale (AHS) of the Psychotic Symptom Rating Scale (PSYRATS), the Quality of Life Scale (QoLS), and the Depression, Anxiety and Stress Scale (DASS). The general results show a variability between subjects, independent of the group they belong to. The time domain showed a higher N1-P3 amplitude post-rTMS, the frequency domain a higher power spectral density (PSD) in the alpha and beta bands, and the connectivity analysis revealed a higher brain network integration (quantified using the participation coefficient) in the beta band. Despite the small number of subjects and the high variability of the results, this work shows a robust data analysis and an interplay between morphology, spectral, and connectivity data. The identification of a trend post-rTMS for each domain in our results is a first step toward the definition of quantitative neurophysiological parameters to assess rTMS treatment. Frontiers Media S.A. 2020-11-20 /pmc/articles/PMC7720634/ /pubmed/33328850 http://dx.doi.org/10.3389/fnins.2020.575538 Text en Copyright © 2020 Aubonnet, Banea, Sirica, Wassermann, Yassine, Jacob, Magnúsdóttir, Haraldsson, Stefansson, Jónasson, Ívarsson, Jónasson, Hassan and Gargiulo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Aubonnet, Romain
Banea, Ovidiu C.
Sirica, Roberta
Wassermann, Eric M.
Yassine, Sahar
Jacob, Deborah
Magnúsdóttir, Brynja Björk
Haraldsson, Magnús
Stefansson, Sigurjon B.
Jónasson, Viktor D.
Ívarsson, Eysteinn
Jónasson, Aron D.
Hassan, Mahmoud
Gargiulo, Paolo
P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations
title P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations
title_full P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations
title_fullStr P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations
title_full_unstemmed P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations
title_short P300 Analysis Using High-Density EEG to Decipher Neural Response to rTMS in Patients With Schizophrenia and Auditory Verbal Hallucinations
title_sort p300 analysis using high-density eeg to decipher neural response to rtms in patients with schizophrenia and auditory verbal hallucinations
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720634/
https://www.ncbi.nlm.nih.gov/pubmed/33328850
http://dx.doi.org/10.3389/fnins.2020.575538
work_keys_str_mv AT aubonnetromain p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT baneaovidiuc p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT siricaroberta p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT wassermannericm p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT yassinesahar p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT jacobdeborah p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT magnusdottirbrynjabjork p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT haraldssonmagnus p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT stefanssonsigurjonb p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT jonassonviktord p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT ivarssoneysteinn p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT jonassonarond p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT hassanmahmoud p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations
AT gargiulopaolo p300analysisusinghighdensityeegtodecipherneuralresponsetortmsinpatientswithschizophreniaandauditoryverbalhallucinations