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Preclinical evaluation of the epithelial sodium channel inhibitor BI 1265162 for treatment of cystic fibrosis

BACKGROUND: Epithelial sodium channel (ENaC) is an important regulator of airway surface liquid volume; ENaC is hyperactivated in cystic fibrosis (CF). ENaC inhibition is a potential therapeutic target for CF. Here, we report in vitro and in vivo results for BI 1265162, an inhaled ENaC inhibitor cur...

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Detalles Bibliográficos
Autores principales:	Nickolaus, Peter, Jung, Birgit, Sabater, Juan, Constant, Samuel, Gupta, Abhya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	European Respiratory Society 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720687/ https://www.ncbi.nlm.nih.gov/pubmed/33313305 http://dx.doi.org/10.1183/23120541.00429-2020

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