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The significance of ovarian fibrosis
Ovarian aging is associated with significant changes in the structural organization of collagen, resulting in ovarian fibrosis. In many other tissues, fibrosis increases risks associated with tumorigenesis and metastasis. Thus, it is possible that ovarian fibrosis increases the risk of ovarian cance...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720769/ https://www.ncbi.nlm.nih.gov/pubmed/33315987 http://dx.doi.org/10.18632/oncotarget.27822 |
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author | Landry, David A. Vaishnav, Het T. Vanderhyden, Barbara C. |
author_facet | Landry, David A. Vaishnav, Het T. Vanderhyden, Barbara C. |
author_sort | Landry, David A. |
collection | PubMed |
description | Ovarian aging is associated with significant changes in the structural organization of collagen, resulting in ovarian fibrosis. In many other tissues, fibrosis increases risks associated with tumorigenesis and metastasis. Thus, it is possible that ovarian fibrosis increases the risk of ovarian cancer by creating a microenvironment more permissive to tumor growth. In this research perspective, we review the impact of female reproduction on the development of ovarian fibrosis and the contributions of genetic and hormonal disruptions such as BRCA mutation, polycystic ovarian syndrome, and infertility to structural changes in the ovary and their relative risk of ovarian cancer. We also explore new fundamental questions in the field of ovarian fibrosis and possible prevention strategies such as metformin. |
format | Online Article Text |
id | pubmed-7720769 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-77207692020-12-10 The significance of ovarian fibrosis Landry, David A. Vaishnav, Het T. Vanderhyden, Barbara C. Oncotarget Research Perspective Ovarian aging is associated with significant changes in the structural organization of collagen, resulting in ovarian fibrosis. In many other tissues, fibrosis increases risks associated with tumorigenesis and metastasis. Thus, it is possible that ovarian fibrosis increases the risk of ovarian cancer by creating a microenvironment more permissive to tumor growth. In this research perspective, we review the impact of female reproduction on the development of ovarian fibrosis and the contributions of genetic and hormonal disruptions such as BRCA mutation, polycystic ovarian syndrome, and infertility to structural changes in the ovary and their relative risk of ovarian cancer. We also explore new fundamental questions in the field of ovarian fibrosis and possible prevention strategies such as metformin. Impact Journals LLC 2020-11-24 /pmc/articles/PMC7720769/ /pubmed/33315987 http://dx.doi.org/10.18632/oncotarget.27822 Text en Copyright: © 2020 Landry et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Perspective Landry, David A. Vaishnav, Het T. Vanderhyden, Barbara C. The significance of ovarian fibrosis |
title | The significance of ovarian fibrosis |
title_full | The significance of ovarian fibrosis |
title_fullStr | The significance of ovarian fibrosis |
title_full_unstemmed | The significance of ovarian fibrosis |
title_short | The significance of ovarian fibrosis |
title_sort | significance of ovarian fibrosis |
topic | Research Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720769/ https://www.ncbi.nlm.nih.gov/pubmed/33315987 http://dx.doi.org/10.18632/oncotarget.27822 |
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