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The Outcome of Unscreened Population in Colorectal Cancer: The Impact of Sex and Other Determinants on Cancer Stage
BACKGROUND: In Saudi Arabia, there is no population-based colorectal cancer (CRC) screening, and more than two-thirds of patients are diagnosed with a late stage. We assessed the association between sex and distant metastasis CRC and hypothesize that females, younger age, non-married, and patients w...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720843/ https://www.ncbi.nlm.nih.gov/pubmed/33299349 http://dx.doi.org/10.2147/CMAR.S268823 |
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author | Alyabsi, Mesnad Sabatin, Fouad Jazieh, Abdul Rahman |
author_facet | Alyabsi, Mesnad Sabatin, Fouad Jazieh, Abdul Rahman |
author_sort | Alyabsi, Mesnad |
collection | PubMed |
description | BACKGROUND: In Saudi Arabia, there is no population-based colorectal cancer (CRC) screening, and more than two-thirds of patients are diagnosed with a late stage. We assessed the association between sex and distant metastasis CRC and hypothesize that females, younger age, non-married, and patients with colon cancer would present with metastatic tumors. PATIENTS AND METHODS: The retrospective cohort study used data from the Ministry of National Guard Cancer Registry. Logistic regression was used to assess the association between sex and metastatic CRC adjusting for patient covariates. In a sensitivity analysis, the association between sex and late-stage CRC was evaluated. RESULTS: A total of 1016 CRC patients met the eligibility criteria, with 37.59% of females and 30.26% of males diagnosed with metastatic CRC. After adjusting for marital status, grade, and morphology, females were 20% more likely than males to present with a metastatic tumor 1.20 (95% CI, 1.04–1.38). CONCLUSION: Although the entire Saudi population would benefit from CRC screening, women may benefit the most from targeted screening. |
format | Online Article Text |
id | pubmed-7720843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-77208432020-12-08 The Outcome of Unscreened Population in Colorectal Cancer: The Impact of Sex and Other Determinants on Cancer Stage Alyabsi, Mesnad Sabatin, Fouad Jazieh, Abdul Rahman Cancer Manag Res Original Research BACKGROUND: In Saudi Arabia, there is no population-based colorectal cancer (CRC) screening, and more than two-thirds of patients are diagnosed with a late stage. We assessed the association between sex and distant metastasis CRC and hypothesize that females, younger age, non-married, and patients with colon cancer would present with metastatic tumors. PATIENTS AND METHODS: The retrospective cohort study used data from the Ministry of National Guard Cancer Registry. Logistic regression was used to assess the association between sex and metastatic CRC adjusting for patient covariates. In a sensitivity analysis, the association between sex and late-stage CRC was evaluated. RESULTS: A total of 1016 CRC patients met the eligibility criteria, with 37.59% of females and 30.26% of males diagnosed with metastatic CRC. After adjusting for marital status, grade, and morphology, females were 20% more likely than males to present with a metastatic tumor 1.20 (95% CI, 1.04–1.38). CONCLUSION: Although the entire Saudi population would benefit from CRC screening, women may benefit the most from targeted screening. Dove 2020-12-01 /pmc/articles/PMC7720843/ /pubmed/33299349 http://dx.doi.org/10.2147/CMAR.S268823 Text en © 2020 Alyabsi et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Alyabsi, Mesnad Sabatin, Fouad Jazieh, Abdul Rahman The Outcome of Unscreened Population in Colorectal Cancer: The Impact of Sex and Other Determinants on Cancer Stage |
title | The Outcome of Unscreened Population in Colorectal Cancer: The Impact of Sex and Other Determinants on Cancer Stage |
title_full | The Outcome of Unscreened Population in Colorectal Cancer: The Impact of Sex and Other Determinants on Cancer Stage |
title_fullStr | The Outcome of Unscreened Population in Colorectal Cancer: The Impact of Sex and Other Determinants on Cancer Stage |
title_full_unstemmed | The Outcome of Unscreened Population in Colorectal Cancer: The Impact of Sex and Other Determinants on Cancer Stage |
title_short | The Outcome of Unscreened Population in Colorectal Cancer: The Impact of Sex and Other Determinants on Cancer Stage |
title_sort | outcome of unscreened population in colorectal cancer: the impact of sex and other determinants on cancer stage |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720843/ https://www.ncbi.nlm.nih.gov/pubmed/33299349 http://dx.doi.org/10.2147/CMAR.S268823 |
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