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Radiotherapy in combination with systemic therapies for brain metastases: current status and progress

Brain metastases (BMs) are the most common cause of intracranial neoplasms in adults with poor prognosis. Most BMs originate from lung cancer, breast cancer, or melanoma. Radiotherapy (RT), including whole brain radiotherapy (WBRT) and stereotactic radiation surgery (SRS), has been widely explored a...

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Autores principales: Liu, Lei, Chen, Wanqi, Zhang, Ruopeng, Wang, Yuekun, Liu, Penghao, Lian, Xin, Zhang, Fuquan, Wang, Yu, Ma, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Compuscript 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721093/
https://www.ncbi.nlm.nih.gov/pubmed/33299643
http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0109
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author Liu, Lei
Chen, Wanqi
Zhang, Ruopeng
Wang, Yuekun
Liu, Penghao
Lian, Xin
Zhang, Fuquan
Wang, Yu
Ma, Wenbin
author_facet Liu, Lei
Chen, Wanqi
Zhang, Ruopeng
Wang, Yuekun
Liu, Penghao
Lian, Xin
Zhang, Fuquan
Wang, Yu
Ma, Wenbin
author_sort Liu, Lei
collection PubMed
description Brain metastases (BMs) are the most common cause of intracranial neoplasms in adults with poor prognosis. Most BMs originate from lung cancer, breast cancer, or melanoma. Radiotherapy (RT), including whole brain radiotherapy (WBRT) and stereotactic radiation surgery (SRS), has been widely explored and is considered a mainstay anticancer treatment for BMs. Over the past decade, the advent of novel systemic therapies has revolutionized the treatment of BMs. In this context, there is a strong rationale for using a combination of treatments based on RT, with the aim of achieving both local disease control and extracranial disease control. This review focuses on describing the latest progress in RT as well as the synergistic effects of the optimal combinations of RT and systemic treatment modalities for BMs, to provide perspectives on current treatments.
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spelling pubmed-77210932020-12-08 Radiotherapy in combination with systemic therapies for brain metastases: current status and progress Liu, Lei Chen, Wanqi Zhang, Ruopeng Wang, Yuekun Liu, Penghao Lian, Xin Zhang, Fuquan Wang, Yu Ma, Wenbin Cancer Biol Med Review Brain metastases (BMs) are the most common cause of intracranial neoplasms in adults with poor prognosis. Most BMs originate from lung cancer, breast cancer, or melanoma. Radiotherapy (RT), including whole brain radiotherapy (WBRT) and stereotactic radiation surgery (SRS), has been widely explored and is considered a mainstay anticancer treatment for BMs. Over the past decade, the advent of novel systemic therapies has revolutionized the treatment of BMs. In this context, there is a strong rationale for using a combination of treatments based on RT, with the aim of achieving both local disease control and extracranial disease control. This review focuses on describing the latest progress in RT as well as the synergistic effects of the optimal combinations of RT and systemic treatment modalities for BMs, to provide perspectives on current treatments. Compuscript 2020-11-15 2020-12-15 /pmc/articles/PMC7721093/ /pubmed/33299643 http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0109 Text en Copyright: © 2020, Cancer Biology & Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0 (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Liu, Lei
Chen, Wanqi
Zhang, Ruopeng
Wang, Yuekun
Liu, Penghao
Lian, Xin
Zhang, Fuquan
Wang, Yu
Ma, Wenbin
Radiotherapy in combination with systemic therapies for brain metastases: current status and progress
title Radiotherapy in combination with systemic therapies for brain metastases: current status and progress
title_full Radiotherapy in combination with systemic therapies for brain metastases: current status and progress
title_fullStr Radiotherapy in combination with systemic therapies for brain metastases: current status and progress
title_full_unstemmed Radiotherapy in combination with systemic therapies for brain metastases: current status and progress
title_short Radiotherapy in combination with systemic therapies for brain metastases: current status and progress
title_sort radiotherapy in combination with systemic therapies for brain metastases: current status and progress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721093/
https://www.ncbi.nlm.nih.gov/pubmed/33299643
http://dx.doi.org/10.20892/j.issn.2095-3941.2020.0109
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