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Oral Exposure to ZnO Nanoparticles Disrupt the Structure of Bone in Young Rats via the OPG/RANK/RANKL/IGF-1 Pathway

PURPOSE: To evaluate the effects of ZnO NPs on bone growth in rats and explore the possible mechanisms of action. MATERIALS AND METHODS: Three-week-old male rats received ultrapure water or 68, 203, and 610 mg/kg zinc oxide nanoparticles (ZnO NPs) for 28 days, orally. RESULTS: The high-dosage groups...

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Detalles Bibliográficos
Autores principales:	Xu, Xinyue, Tang, Yizhou, Lang, Yuanyuan, Liu, Yanling, Cheng, Wenshu, Xu, Hengyi, Liu, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721121/ https://www.ncbi.nlm.nih.gov/pubmed/33299310 http://dx.doi.org/10.2147/IJN.S275553

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