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Cortical thickness as predictor of response to exercise in people with Parkinson's disease
We previously showed that dual‐task cost (DTC) on gait speed in people with Parkinson's disease (PD) improved after 6 weeks of the Agility Boot Camp with Cognitive Challenge (ABC‐C) exercise program. Since deficits in dual‐task gait speed are associated with freezing of gait and gray matter atr...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721225/ https://www.ncbi.nlm.nih.gov/pubmed/33035370 http://dx.doi.org/10.1002/hbm.25211 |
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author | Silva‐Batista, Carla Ragothaman, Anjanibhargavi Mancini, Martina Carlson‐Kuhta, Patricia Harker, Graham Jung, Se Hee Nutt, John G. Fair, Damien A Horak, Fay B. Miranda‐Domínguez, Oscar |
author_facet | Silva‐Batista, Carla Ragothaman, Anjanibhargavi Mancini, Martina Carlson‐Kuhta, Patricia Harker, Graham Jung, Se Hee Nutt, John G. Fair, Damien A Horak, Fay B. Miranda‐Domínguez, Oscar |
author_sort | Silva‐Batista, Carla |
collection | PubMed |
description | We previously showed that dual‐task cost (DTC) on gait speed in people with Parkinson's disease (PD) improved after 6 weeks of the Agility Boot Camp with Cognitive Challenge (ABC‐C) exercise program. Since deficits in dual‐task gait speed are associated with freezing of gait and gray matter atrophy, here we performed preplanned secondary analyses to answer two questions: (a) Do people with PD who are freezers present similar improvements compared to nonfreezers in DTC on gait speed with ABC‐C? (b) Can cortical thickness at baseline predict responsiveness to the ABC‐C? The DTC from 39 freezers and 43 nonfreezers who completed 6 weeks of ABC‐C were analyzed. A subset of 51 participants (21 freezers and 30 nonfreezers) with high quality imaging data were used to characterize relationships between baseline cortical thickness and delta (Δ) DTC on gait speed following ABC‐C. Freezers showed larger ΔDTC on gait speed than nonfreezers with ABC‐C program (p < .05). Cortical thickness in visual and fronto‐parietal areas predicted ΔDTC on gait speed in freezers, whereas sensorimotor‐lateral thickness predicted ΔDTC on gait speed in nonfreezers (p < .05). When matched for motor severity, visual cortical thickness was a common predictor of response to exercise in all individuals, presenting the largest effect size. In conclusion, freezers improved gait automaticity even more than nonfreezers from cognitively challenging exercise. DTC on gait speed improvement was associated with larger baseline cortical thickness from different brain areas, depending on freezing status, but visual cortex thickness showed the most robust relationship with exercise‐induced improvements in DTC. |
format | Online Article Text |
id | pubmed-7721225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77212252020-12-11 Cortical thickness as predictor of response to exercise in people with Parkinson's disease Silva‐Batista, Carla Ragothaman, Anjanibhargavi Mancini, Martina Carlson‐Kuhta, Patricia Harker, Graham Jung, Se Hee Nutt, John G. Fair, Damien A Horak, Fay B. Miranda‐Domínguez, Oscar Hum Brain Mapp Research Articles We previously showed that dual‐task cost (DTC) on gait speed in people with Parkinson's disease (PD) improved after 6 weeks of the Agility Boot Camp with Cognitive Challenge (ABC‐C) exercise program. Since deficits in dual‐task gait speed are associated with freezing of gait and gray matter atrophy, here we performed preplanned secondary analyses to answer two questions: (a) Do people with PD who are freezers present similar improvements compared to nonfreezers in DTC on gait speed with ABC‐C? (b) Can cortical thickness at baseline predict responsiveness to the ABC‐C? The DTC from 39 freezers and 43 nonfreezers who completed 6 weeks of ABC‐C were analyzed. A subset of 51 participants (21 freezers and 30 nonfreezers) with high quality imaging data were used to characterize relationships between baseline cortical thickness and delta (Δ) DTC on gait speed following ABC‐C. Freezers showed larger ΔDTC on gait speed than nonfreezers with ABC‐C program (p < .05). Cortical thickness in visual and fronto‐parietal areas predicted ΔDTC on gait speed in freezers, whereas sensorimotor‐lateral thickness predicted ΔDTC on gait speed in nonfreezers (p < .05). When matched for motor severity, visual cortical thickness was a common predictor of response to exercise in all individuals, presenting the largest effect size. In conclusion, freezers improved gait automaticity even more than nonfreezers from cognitively challenging exercise. DTC on gait speed improvement was associated with larger baseline cortical thickness from different brain areas, depending on freezing status, but visual cortex thickness showed the most robust relationship with exercise‐induced improvements in DTC. John Wiley & Sons, Inc. 2020-10-09 /pmc/articles/PMC7721225/ /pubmed/33035370 http://dx.doi.org/10.1002/hbm.25211 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Silva‐Batista, Carla Ragothaman, Anjanibhargavi Mancini, Martina Carlson‐Kuhta, Patricia Harker, Graham Jung, Se Hee Nutt, John G. Fair, Damien A Horak, Fay B. Miranda‐Domínguez, Oscar Cortical thickness as predictor of response to exercise in people with Parkinson's disease |
title | Cortical thickness as predictor of response to exercise in people with Parkinson's disease |
title_full | Cortical thickness as predictor of response to exercise in people with Parkinson's disease |
title_fullStr | Cortical thickness as predictor of response to exercise in people with Parkinson's disease |
title_full_unstemmed | Cortical thickness as predictor of response to exercise in people with Parkinson's disease |
title_short | Cortical thickness as predictor of response to exercise in people with Parkinson's disease |
title_sort | cortical thickness as predictor of response to exercise in people with parkinson's disease |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721225/ https://www.ncbi.nlm.nih.gov/pubmed/33035370 http://dx.doi.org/10.1002/hbm.25211 |
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