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Cortical reorganization following auditory deprivation predicts cochlear implant performance in postlingually deaf adults

Long‐term hearing loss in postlingually deaf (PD) adults may lead to brain structural changes that affect the outcomes of cochlear implantation. We studied 94 PD patients who underwent cochlear implantation and 37 patients who were MRI‐scanned within 2 weeks after the onset of sudden hearing loss an...

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Autores principales: Sun, Zhe, Seo, Ji Won, Park, Hong Ju, Lee, Jee Yeon, Kwak, Min Young, Kim, Yehree, Lee, Je Yeon, Park, Jun Woo, Kang, Woo Seok, Ahn, Joong Ho, Chung, Jong Woo, Kim, Hosung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721232/
https://www.ncbi.nlm.nih.gov/pubmed/33022826
http://dx.doi.org/10.1002/hbm.25219
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author Sun, Zhe
Seo, Ji Won
Park, Hong Ju
Lee, Jee Yeon
Kwak, Min Young
Kim, Yehree
Lee, Je Yeon
Park, Jun Woo
Kang, Woo Seok
Ahn, Joong Ho
Chung, Jong Woo
Kim, Hosung
author_facet Sun, Zhe
Seo, Ji Won
Park, Hong Ju
Lee, Jee Yeon
Kwak, Min Young
Kim, Yehree
Lee, Je Yeon
Park, Jun Woo
Kang, Woo Seok
Ahn, Joong Ho
Chung, Jong Woo
Kim, Hosung
author_sort Sun, Zhe
collection PubMed
description Long‐term hearing loss in postlingually deaf (PD) adults may lead to brain structural changes that affect the outcomes of cochlear implantation. We studied 94 PD patients who underwent cochlear implantation and 37 patients who were MRI‐scanned within 2 weeks after the onset of sudden hearing loss and expected with minimal brain structural changes in relation to deafness. Compared with those with sudden hearing loss, we found lower gray matter (GM) probabilities in bilateral thalami, superior, middle, inferior temporal cortices as well as the central cortical regions corresponding to the movement and sensation of the lips, tongue, and larynx in the PD group. Among these brain areas, the GM in the middle temporal cortex showed negative correlation with disease duration, whereas the other areas displayed positive correlations. Left superior, middle temporal cortical, and bilateral thalamic GMs were the most accurate predictors of post‐cochlear implantation word recognition scores (mean absolute error [MAE] = 10.1, r = .82), which was superior to clinical variables used (MAE: 12.1, p < .05). Using the combined brain morphological and clinical features, we achieved the best prediction of the outcome (MAE: 8.51, r = .90). Our findings suggest that the cross‐modal plasticity allowing the superior temporal cortex and thalamus to process other modal sensory inputs reverses the initially lower volume when deafness becomes persistent. The middle temporal cortex processing higher‐level language comprehension shows persistent negative correlations with disease duration, suggesting this area's association with degraded speech comprehensions due to long‐term deafness. Morphological features combined with clinical variables might play a key role in predicting outcomes of cochlear implantation.
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spelling pubmed-77212322020-12-11 Cortical reorganization following auditory deprivation predicts cochlear implant performance in postlingually deaf adults Sun, Zhe Seo, Ji Won Park, Hong Ju Lee, Jee Yeon Kwak, Min Young Kim, Yehree Lee, Je Yeon Park, Jun Woo Kang, Woo Seok Ahn, Joong Ho Chung, Jong Woo Kim, Hosung Hum Brain Mapp Research Articles Long‐term hearing loss in postlingually deaf (PD) adults may lead to brain structural changes that affect the outcomes of cochlear implantation. We studied 94 PD patients who underwent cochlear implantation and 37 patients who were MRI‐scanned within 2 weeks after the onset of sudden hearing loss and expected with minimal brain structural changes in relation to deafness. Compared with those with sudden hearing loss, we found lower gray matter (GM) probabilities in bilateral thalami, superior, middle, inferior temporal cortices as well as the central cortical regions corresponding to the movement and sensation of the lips, tongue, and larynx in the PD group. Among these brain areas, the GM in the middle temporal cortex showed negative correlation with disease duration, whereas the other areas displayed positive correlations. Left superior, middle temporal cortical, and bilateral thalamic GMs were the most accurate predictors of post‐cochlear implantation word recognition scores (mean absolute error [MAE] = 10.1, r = .82), which was superior to clinical variables used (MAE: 12.1, p < .05). Using the combined brain morphological and clinical features, we achieved the best prediction of the outcome (MAE: 8.51, r = .90). Our findings suggest that the cross‐modal plasticity allowing the superior temporal cortex and thalamus to process other modal sensory inputs reverses the initially lower volume when deafness becomes persistent. The middle temporal cortex processing higher‐level language comprehension shows persistent negative correlations with disease duration, suggesting this area's association with degraded speech comprehensions due to long‐term deafness. Morphological features combined with clinical variables might play a key role in predicting outcomes of cochlear implantation. John Wiley & Sons, Inc. 2020-10-06 /pmc/articles/PMC7721232/ /pubmed/33022826 http://dx.doi.org/10.1002/hbm.25219 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Sun, Zhe
Seo, Ji Won
Park, Hong Ju
Lee, Jee Yeon
Kwak, Min Young
Kim, Yehree
Lee, Je Yeon
Park, Jun Woo
Kang, Woo Seok
Ahn, Joong Ho
Chung, Jong Woo
Kim, Hosung
Cortical reorganization following auditory deprivation predicts cochlear implant performance in postlingually deaf adults
title Cortical reorganization following auditory deprivation predicts cochlear implant performance in postlingually deaf adults
title_full Cortical reorganization following auditory deprivation predicts cochlear implant performance in postlingually deaf adults
title_fullStr Cortical reorganization following auditory deprivation predicts cochlear implant performance in postlingually deaf adults
title_full_unstemmed Cortical reorganization following auditory deprivation predicts cochlear implant performance in postlingually deaf adults
title_short Cortical reorganization following auditory deprivation predicts cochlear implant performance in postlingually deaf adults
title_sort cortical reorganization following auditory deprivation predicts cochlear implant performance in postlingually deaf adults
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721232/
https://www.ncbi.nlm.nih.gov/pubmed/33022826
http://dx.doi.org/10.1002/hbm.25219
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