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Estrogen, brain structure, and cognition in postmenopausal women

Declining estrogen levels before, during, and after menopause can affect memory and risk for Alzheimer's disease. Undesirable side effects of hormone variations emphasize a role for hormone therapy (HT) where possible benefits include a delay in the onset of dementia—yet findings are inconsiste...

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Autores principales: Boyle, Christina P., Raji, Cyrus A., Erickson, Kirk I., Lopez, Oscar L., Becker, James T., Gach, H. Michael, Kuller, Lewis H., Longstreth, William, Carmichael, Owen T., Riedel, Brandalyn C., Thompson, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721237/
https://www.ncbi.nlm.nih.gov/pubmed/32910516
http://dx.doi.org/10.1002/hbm.25200
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author Boyle, Christina P.
Raji, Cyrus A.
Erickson, Kirk I.
Lopez, Oscar L.
Becker, James T.
Gach, H. Michael
Kuller, Lewis H.
Longstreth, William
Carmichael, Owen T.
Riedel, Brandalyn C.
Thompson, Paul M.
author_facet Boyle, Christina P.
Raji, Cyrus A.
Erickson, Kirk I.
Lopez, Oscar L.
Becker, James T.
Gach, H. Michael
Kuller, Lewis H.
Longstreth, William
Carmichael, Owen T.
Riedel, Brandalyn C.
Thompson, Paul M.
author_sort Boyle, Christina P.
collection PubMed
description Declining estrogen levels before, during, and after menopause can affect memory and risk for Alzheimer's disease. Undesirable side effects of hormone variations emphasize a role for hormone therapy (HT) where possible benefits include a delay in the onset of dementia—yet findings are inconsistent. Effects of HT may be mediated by estrogen receptors found throughout the brain. Effects may also depend on lifestyle factors, timing of use, and genetic risk. We studied the impact of self‐reported HT use on brain volume in 562 elderly women (71–94 years) with mixed cognitive status while adjusting for aforementioned factors. Covariate‐adjusted voxelwise linear regression analyses using a model with 16 predictors showed HT use as positively associated with regional brain volumes, regardless of cognitive status. Examinations of other factors related to menopause, oophorectomy and hysterectomy status independently yielded positive effects on brain volume when added to our model. One interaction term, HTxBMI, out of several examined, revealed significant negative association with overall brain volume, suggesting a greater reduction in brain volume than BMI alone. Our main findings relating HT to regional brain volume were as hypothesized, but some exploratory analyses were not in line with existing hypotheses. Studies suggest lower levels of estrogen resulting from oophorectomy and hysterectomy affect brain volume negatively, and the addition of HT modifies the relation between BMI and brain volume positively. Effects of HT may depend on the age range assessed, motivating studies with a wider age range as well as a randomized design.
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spelling pubmed-77212372020-12-11 Estrogen, brain structure, and cognition in postmenopausal women Boyle, Christina P. Raji, Cyrus A. Erickson, Kirk I. Lopez, Oscar L. Becker, James T. Gach, H. Michael Kuller, Lewis H. Longstreth, William Carmichael, Owen T. Riedel, Brandalyn C. Thompson, Paul M. Hum Brain Mapp Research Articles Declining estrogen levels before, during, and after menopause can affect memory and risk for Alzheimer's disease. Undesirable side effects of hormone variations emphasize a role for hormone therapy (HT) where possible benefits include a delay in the onset of dementia—yet findings are inconsistent. Effects of HT may be mediated by estrogen receptors found throughout the brain. Effects may also depend on lifestyle factors, timing of use, and genetic risk. We studied the impact of self‐reported HT use on brain volume in 562 elderly women (71–94 years) with mixed cognitive status while adjusting for aforementioned factors. Covariate‐adjusted voxelwise linear regression analyses using a model with 16 predictors showed HT use as positively associated with regional brain volumes, regardless of cognitive status. Examinations of other factors related to menopause, oophorectomy and hysterectomy status independently yielded positive effects on brain volume when added to our model. One interaction term, HTxBMI, out of several examined, revealed significant negative association with overall brain volume, suggesting a greater reduction in brain volume than BMI alone. Our main findings relating HT to regional brain volume were as hypothesized, but some exploratory analyses were not in line with existing hypotheses. Studies suggest lower levels of estrogen resulting from oophorectomy and hysterectomy affect brain volume negatively, and the addition of HT modifies the relation between BMI and brain volume positively. Effects of HT may depend on the age range assessed, motivating studies with a wider age range as well as a randomized design. John Wiley & Sons, Inc. 2020-09-10 /pmc/articles/PMC7721237/ /pubmed/32910516 http://dx.doi.org/10.1002/hbm.25200 Text en © 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Boyle, Christina P.
Raji, Cyrus A.
Erickson, Kirk I.
Lopez, Oscar L.
Becker, James T.
Gach, H. Michael
Kuller, Lewis H.
Longstreth, William
Carmichael, Owen T.
Riedel, Brandalyn C.
Thompson, Paul M.
Estrogen, brain structure, and cognition in postmenopausal women
title Estrogen, brain structure, and cognition in postmenopausal women
title_full Estrogen, brain structure, and cognition in postmenopausal women
title_fullStr Estrogen, brain structure, and cognition in postmenopausal women
title_full_unstemmed Estrogen, brain structure, and cognition in postmenopausal women
title_short Estrogen, brain structure, and cognition in postmenopausal women
title_sort estrogen, brain structure, and cognition in postmenopausal women
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721237/
https://www.ncbi.nlm.nih.gov/pubmed/32910516
http://dx.doi.org/10.1002/hbm.25200
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