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Prognostic Significance of Homocysteine Level on Neurological Outcome in Brain Arteriovenous Malformations

OBJECTIVE: We aimed to investigate the serum homocysteine (Hcy) level in patients with brain arteriovenous malformation (bAVM) and their impact on neurological outcome during hospitalization. METHOD: We retrospectively reviewed patients diagnosed with bAVMs in Beijing Tiantan Hospital from January 2...

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Autores principales: Lin, Fa, Zeng, Chaofan, Ge, Peicong, Zhang, Dong, Wang, Shuo, Zhao, Jizong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721487/
https://www.ncbi.nlm.nih.gov/pubmed/33312268
http://dx.doi.org/10.1155/2020/6661475
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author Lin, Fa
Zeng, Chaofan
Ge, Peicong
Zhang, Dong
Wang, Shuo
Zhao, Jizong
author_facet Lin, Fa
Zeng, Chaofan
Ge, Peicong
Zhang, Dong
Wang, Shuo
Zhao, Jizong
author_sort Lin, Fa
collection PubMed
description OBJECTIVE: We aimed to investigate the serum homocysteine (Hcy) level in patients with brain arteriovenous malformation (bAVM) and their impact on neurological outcome during hospitalization. METHOD: We retrospectively reviewed patients diagnosed with bAVMs in Beijing Tiantan Hospital from January 2019 to August 2020. Patients were divided into two groups according to the mRS (modified Rankin Scale) score at discharge. Clinical and laboratory characteristics were compared. Logistic regression analyses were performed to identify the potential risk factors for short-term neurological outcome. RESULTS: A total of 175 bAVM patients were enrolled in the study, including 139 patients with favorable outcome (mRS ≤ 2) and 36 patients with unfavorable outcome (mRS > 2). Hyperhomocysteinemia was identified in 32.6% of cases (n = 57). Serum Hcy level was related to seizure manifestation (P = 0.034) and short-term neurological outcome (P = 0.027). Logistic regression analysis showed that serum glucose (OR 1.897, 95% CI 1.115-3.229; P = 0.018) and Hcy level (OR 0.838, 95% CI 0.720-0.976; P = 0.023) were significantly associated with short-term disability. CONCLUSION: Our results indicated that the lower serum Hcy level is strongly associated with in-hospital unfavorable outcome. Further prospective studies of Hcy natural history and managements in bAVMs are required, which would be valuable for evaluating the disease-modifying efficacy of oral nutritional supplements in bAVM patients.
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spelling pubmed-77214872020-12-11 Prognostic Significance of Homocysteine Level on Neurological Outcome in Brain Arteriovenous Malformations Lin, Fa Zeng, Chaofan Ge, Peicong Zhang, Dong Wang, Shuo Zhao, Jizong Dis Markers Research Article OBJECTIVE: We aimed to investigate the serum homocysteine (Hcy) level in patients with brain arteriovenous malformation (bAVM) and their impact on neurological outcome during hospitalization. METHOD: We retrospectively reviewed patients diagnosed with bAVMs in Beijing Tiantan Hospital from January 2019 to August 2020. Patients were divided into two groups according to the mRS (modified Rankin Scale) score at discharge. Clinical and laboratory characteristics were compared. Logistic regression analyses were performed to identify the potential risk factors for short-term neurological outcome. RESULTS: A total of 175 bAVM patients were enrolled in the study, including 139 patients with favorable outcome (mRS ≤ 2) and 36 patients with unfavorable outcome (mRS > 2). Hyperhomocysteinemia was identified in 32.6% of cases (n = 57). Serum Hcy level was related to seizure manifestation (P = 0.034) and short-term neurological outcome (P = 0.027). Logistic regression analysis showed that serum glucose (OR 1.897, 95% CI 1.115-3.229; P = 0.018) and Hcy level (OR 0.838, 95% CI 0.720-0.976; P = 0.023) were significantly associated with short-term disability. CONCLUSION: Our results indicated that the lower serum Hcy level is strongly associated with in-hospital unfavorable outcome. Further prospective studies of Hcy natural history and managements in bAVMs are required, which would be valuable for evaluating the disease-modifying efficacy of oral nutritional supplements in bAVM patients. Hindawi 2020-11-30 /pmc/articles/PMC7721487/ /pubmed/33312268 http://dx.doi.org/10.1155/2020/6661475 Text en Copyright © 2020 Fa Lin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Lin, Fa
Zeng, Chaofan
Ge, Peicong
Zhang, Dong
Wang, Shuo
Zhao, Jizong
Prognostic Significance of Homocysteine Level on Neurological Outcome in Brain Arteriovenous Malformations
title Prognostic Significance of Homocysteine Level on Neurological Outcome in Brain Arteriovenous Malformations
title_full Prognostic Significance of Homocysteine Level on Neurological Outcome in Brain Arteriovenous Malformations
title_fullStr Prognostic Significance of Homocysteine Level on Neurological Outcome in Brain Arteriovenous Malformations
title_full_unstemmed Prognostic Significance of Homocysteine Level on Neurological Outcome in Brain Arteriovenous Malformations
title_short Prognostic Significance of Homocysteine Level on Neurological Outcome in Brain Arteriovenous Malformations
title_sort prognostic significance of homocysteine level on neurological outcome in brain arteriovenous malformations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721487/
https://www.ncbi.nlm.nih.gov/pubmed/33312268
http://dx.doi.org/10.1155/2020/6661475
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