Cargando…

Cell-Permeable Bak BH3 Peptide Induces Chemosensitization of Hematologic Malignant Cells

Hematologic malignancies such as leukemias and lymphomas are among the leading causes of pediatric cancer death worldwide, and although survival rates have improved with conventional treatments, the development of drug-resistant cancer cells may lead to patient relapse and limited possibilities of a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ugarte-Alvarez, Omar, Muñoz-López, Paola, Moreno-Vargas, Liliana Marisol, Prada-Gracia, Diego, Mateos-Chávez, Armando Alfredo, Becerra-Báez, Elayne Irene, Luria-Pérez, Rosendo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721494/ https://www.ncbi.nlm.nih.gov/pubmed/33312200 http://dx.doi.org/10.1155/2020/2679046

Ejemplares similares

Live Attenuated Salmonella enterica Expressing and Releasing Cell-Permeable Bax BH3 Peptide Through the MisL Autotransporter System Elicits Antitumor Activity in a Murine Xenograft Model of Human B Non-hodgkin's Lymphoma
por: Mateos-Chávez, Armando Alfredo, et al.
Publicado: (2019)

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization
por: Dai, Haiming, et al.
Publicado: (2011)

Single-Chain Fragment Variable: Recent Progress in Cancer Diagnosis and Therapy
por: Muñoz-López, Paola, et al.
Publicado: (2022)

Characterization of an alternative BAK-binding site for BH3 peptides
por: Ye, Kaiqin, et al.
Publicado: (2020)

Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization
por: Pang, Yuan-Ping, et al.
Publicado: (2012)

BH3 Peptides Induce Mitochondrial Fission and Cell Death Independent of BAX/BAK
por: Shroff, Emelyn H., et al.
Publicado: (2009)

Inhibition of the Anti-Apoptotic Bcl-2 Family by BH3 Mimetics Sensitize the Mitochondrial Permeability Transition Pore Through Bax and Bak
por: Patel, Pooja, et al.
Publicado: (2021)

Recombinant Attenuated Salmonella enterica as a Delivery System of Heterologous Molecules in Cancer Therapy
por: Becerra-Báez, Elayne Irene, et al.
Publicado: (2022)

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax
por: Hockings, C, et al.
Publicado: (2015)

Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions
por: Finnegan, N M, et al.
Publicado: (2001)

Dynamical Systems Analysis of Mitochondrial BAK Activation Kinetics Predicts Resistance to BH3 Domains
por: Grills, Claire, et al.
Publicado: (2008)

Structural basis for proapoptotic activation of Bak by the noncanonical BH3-only protein Pxt1
por: Lim, Dahwan, et al.
Publicado: (2023)

Autophagic cell death is dependent on lysosomal membrane permeability through Bax and Bak
por: Karch, Jason, et al.
Publicado: (2017)

Pancreatic β-Cell Death due to Pdx-1 Deficiency Requires Multi-BH Domain Protein Bax but Not Bak
por: Sun, Juan, et al.
Publicado: (2016)

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins
por: Goodall, Katharine J., et al.
Publicado: (2016)

mRNA for N-Bak, a neuron-specific BH3-only splice isoform of Bak, escapes nonsense-mediated decay and is translationally repressed in the neurons
por: Jakobson, M, et al.
Publicado: (2012)

BH3 Mimetics in Hematologic Malignancies
por: Klener, Pavel, et al.
Publicado: (2021)

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak
por: Uren, Rachel T., et al.
Publicado: (2007)

The VDAC2–BAK axis regulates peroxisomal membrane permeability
por: Hosoi, Ken-ichiro, et al.
Publicado: (2017)

Sensitivity of canine hematological cancers to BH3 mimetics
por: Jegatheeson, Selvi, et al.
Publicado: (2022)

Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells
por: Papaianni, Emanuela, et al.
Publicado: (2015)

Contribution of BH3-domain and Transmembrane-domain to the Activity and Interaction of the Pore-forming Bcl-2 Proteins Bok, Bak, and Bax
por: Stehle, Daniel, et al.
Publicado: (2018)

Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice
por: Karch, Jason, et al.
Publicado: (2013)

In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-X(L) and Mcl-1 but in the absence of active BH3-only proteins
por: Senft, D, et al.
Publicado: (2015)

BAK-up: the receptor kinase BAK-TO-LIFE 2 enhances immunity when BAK1 is lacking
por: Fallahzadeh-Mamaghami, Vahid, et al.
Publicado: (2023)

Playing FullBAK
por: Walensky, Loren D.
Publicado: (2013)

Cancer chemoresistance and BAK
por: Fox, Joanna L.
Publicado: (2015)

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target
por: Iyer, Sweta, et al.
Publicado: (2020)

Paradoxical implication of BAX/BAK in the persistence of tetraploid cells
por: Deng, Jiayin, et al.
Publicado: (2021)

Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies
por: Al-Zebeeby, Aoula, et al.
Publicado: (2019)

Bak activators get in the groove
por: Leslie, Mitch
Publicado: (2011)

BAK additive influence on results
por: Shah, Rupali D, et al.
Publicado: (2013)

The great migration of Bax and Bak
por: Edlich, Frank
Publicado: (2015)

BÄK: Zehn-Punkte-Plan
por: Landschek, Ines
Publicado: (2020)

BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove
por: Azad, Abul, et al.
Publicado: (2013)

Brain and Testicular Tumors in Mice with Progenitor Cells Lacking BAX and BAK
por: Katz, Samuel G., et al.
Publicado: (2012)

Physiological restraint of Bak by Bcl-x(L) is essential for cell survival
por: Lee, Erinna F., et al.
Publicado: (2016)

A beam destination read-out for BH3∕BH4
por: Tanke, E
Publicado: (1984)

Interface de controle de BH3 et BH4
por: Liénard, P
Publicado: (1984)

High pressure polymorphism of LiBH(4) and of NaBH(4)
por: Marizy, Adrien, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_jut9kjuemva37vp353kpfgshkd