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Role of SPTSSB-Regulated de Novo Sphingolipid Synthesis in Prostate Cancer Depends on Androgen Receptor Signaling

Anti-androgens are a common therapy in prostate cancer (PCa) targeting androgen receptor (AR) signaling. However, these therapies fail due to selection of highly aggressive AR-negative cancer cells that have no therapeutic options available. We demonstrate that elevating endogenous ceramide levels w...

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Detalles Bibliográficos
Autores principales:	Costa-Pinheiro, Pedro, Heher, Abigail, Raymond, Michael H., Jividen, Kasey, Shaw, Jeremy JP., Paschal, Bryce M., Walker, Susan J., Fox, Todd E., Kester, Mark
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721643/ https://www.ncbi.nlm.nih.gov/pubmed/33313495 http://dx.doi.org/10.1016/j.isci.2020.101855

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