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Alveolar rhabdomyosarcoma of the mandible in an adult invading the parotid gland: A rare case report

INTRODUCTION: Rhabdomyosarcoma (RMS) is a malignant mesenchymal neoplasm uncommon in adults. PRESENTATION OF CASE: We report the case of an alveolar rhabdomyosarcoma in a rare location and in an adult. It concerns a 46-year-old woman with a mandibular location invading the parotid gland. The Immunoh...

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Autores principales: Yassir, Hammouda, Ngham, Hicham, Lyoubi, Mouna, Abada, Reda Allah, Oukessou, Youssef, Roubal, Mohammed, Mahtar, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721655/
https://www.ncbi.nlm.nih.gov/pubmed/33395910
http://dx.doi.org/10.1016/j.ijscr.2020.10.052
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author Yassir, Hammouda
Ngham, Hicham
Lyoubi, Mouna
Abada, Reda Allah
Oukessou, Youssef
Roubal, Mohammed
Mahtar, Mohammed
author_facet Yassir, Hammouda
Ngham, Hicham
Lyoubi, Mouna
Abada, Reda Allah
Oukessou, Youssef
Roubal, Mohammed
Mahtar, Mohammed
author_sort Yassir, Hammouda
collection PubMed
description INTRODUCTION: Rhabdomyosarcoma (RMS) is a malignant mesenchymal neoplasm uncommon in adults. PRESENTATION OF CASE: We report the case of an alveolar rhabdomyosarcoma in a rare location and in an adult. It concerns a 46-year-old woman with a mandibular location invading the parotid gland. The Immunohistochemical analysis revealed intense positivity for myogenin and desmin, favoring the diagnosis of alveolar rhabdomyosarcoma. The patient had a right hemi-mandibulectomy with parotidectomy and received chemotherapy with radiotherapy. The evolution was good up to 2 years postoperatively then the patient relapsed with a recurrence of tumour rapidly progressing and metastases in the cervical spine. DISCUSSION: RMS is an aggressive but rare disease that is one of the most common malignant head and neck tumors in children. The predilection sites of adult rhabdomyosarcoma are the extremities. Current treatment includes a combination of ablative surgery, chemotherapy, and radiation therapy. CONCLUSION: The prognosis of head and neck rhabdomyosarcomas in adults remains very poor given the often initially advanced stage of the disease and the high metastatic potential.
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spelling pubmed-77216552020-12-11 Alveolar rhabdomyosarcoma of the mandible in an adult invading the parotid gland: A rare case report Yassir, Hammouda Ngham, Hicham Lyoubi, Mouna Abada, Reda Allah Oukessou, Youssef Roubal, Mohammed Mahtar, Mohammed Int J Surg Case Rep Case Report INTRODUCTION: Rhabdomyosarcoma (RMS) is a malignant mesenchymal neoplasm uncommon in adults. PRESENTATION OF CASE: We report the case of an alveolar rhabdomyosarcoma in a rare location and in an adult. It concerns a 46-year-old woman with a mandibular location invading the parotid gland. The Immunohistochemical analysis revealed intense positivity for myogenin and desmin, favoring the diagnosis of alveolar rhabdomyosarcoma. The patient had a right hemi-mandibulectomy with parotidectomy and received chemotherapy with radiotherapy. The evolution was good up to 2 years postoperatively then the patient relapsed with a recurrence of tumour rapidly progressing and metastases in the cervical spine. DISCUSSION: RMS is an aggressive but rare disease that is one of the most common malignant head and neck tumors in children. The predilection sites of adult rhabdomyosarcoma are the extremities. Current treatment includes a combination of ablative surgery, chemotherapy, and radiation therapy. CONCLUSION: The prognosis of head and neck rhabdomyosarcomas in adults remains very poor given the often initially advanced stage of the disease and the high metastatic potential. Elsevier 2020-11-23 /pmc/articles/PMC7721655/ /pubmed/33395910 http://dx.doi.org/10.1016/j.ijscr.2020.10.052 Text en © 2020 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yassir, Hammouda
Ngham, Hicham
Lyoubi, Mouna
Abada, Reda Allah
Oukessou, Youssef
Roubal, Mohammed
Mahtar, Mohammed
Alveolar rhabdomyosarcoma of the mandible in an adult invading the parotid gland: A rare case report
title Alveolar rhabdomyosarcoma of the mandible in an adult invading the parotid gland: A rare case report
title_full Alveolar rhabdomyosarcoma of the mandible in an adult invading the parotid gland: A rare case report
title_fullStr Alveolar rhabdomyosarcoma of the mandible in an adult invading the parotid gland: A rare case report
title_full_unstemmed Alveolar rhabdomyosarcoma of the mandible in an adult invading the parotid gland: A rare case report
title_short Alveolar rhabdomyosarcoma of the mandible in an adult invading the parotid gland: A rare case report
title_sort alveolar rhabdomyosarcoma of the mandible in an adult invading the parotid gland: a rare case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721655/
https://www.ncbi.nlm.nih.gov/pubmed/33395910
http://dx.doi.org/10.1016/j.ijscr.2020.10.052
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