Cargando…
Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity
The current study aimed to investigate whether the in vivo availability of central serotonin reuptake transporters (5-HTT) is associated with plasma levels of glycosylated hemoglobin (HbA1c) in non-diabetic humans with obesity. 5-HTT availability was measured by using positron emission tomography (P...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721891/ https://www.ncbi.nlm.nih.gov/pubmed/33288788 http://dx.doi.org/10.1038/s41598-020-78227-z |
_version_ | 1783620106103816192 |
---|---|
author | Grundmann, Rico Rullmann, Michael Luthardt, Julia Zientek, Franziska Becker, Georg-Alexander Patt, Marianne Hankir, Mohammed K. Blüher, Matthias Sabri, Osama Hesse, Swen |
author_facet | Grundmann, Rico Rullmann, Michael Luthardt, Julia Zientek, Franziska Becker, Georg-Alexander Patt, Marianne Hankir, Mohammed K. Blüher, Matthias Sabri, Osama Hesse, Swen |
author_sort | Grundmann, Rico |
collection | PubMed |
description | The current study aimed to investigate whether the in vivo availability of central serotonin reuptake transporters (5-HTT) is associated with plasma levels of glycosylated hemoglobin (HbA1c) in non-diabetic humans with obesity. 5-HTT availability was measured by using positron emission tomography (PET) imaging with the 5-HTT selective radiotracer [(11)C]DASB in 23 non-diabetic individuals with obesity and 14 healthy, non-obesity controls. Parametric images of binding potential BP(ND) were generated from the PET data and analyzed together with HbA1c levels by using volume of interest analysis for brain areas relevant to appetite control. Voxel-based morphometry (VBM) of individual magnetic resonance imaging data was further performed to correlate grey matter density (GMD) maps with HbA1c. We found significant negative correlations between HbA1c levels and BP(ND) in right and left hippocampus in obesity (r = − 0.717, p < 0.001, and r = − 0.557, p = 0.006, respectively). VBM analyses revealed that higher HbA1c levels were associated with GMD in the right para-hippocampal area. Our results indicate that chronically high blood glucose levels may evoke changes in hippocampal 5-HTT levels that are in part tied to local microstructure. |
format | Online Article Text |
id | pubmed-7721891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77218912020-12-09 Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity Grundmann, Rico Rullmann, Michael Luthardt, Julia Zientek, Franziska Becker, Georg-Alexander Patt, Marianne Hankir, Mohammed K. Blüher, Matthias Sabri, Osama Hesse, Swen Sci Rep Article The current study aimed to investigate whether the in vivo availability of central serotonin reuptake transporters (5-HTT) is associated with plasma levels of glycosylated hemoglobin (HbA1c) in non-diabetic humans with obesity. 5-HTT availability was measured by using positron emission tomography (PET) imaging with the 5-HTT selective radiotracer [(11)C]DASB in 23 non-diabetic individuals with obesity and 14 healthy, non-obesity controls. Parametric images of binding potential BP(ND) were generated from the PET data and analyzed together with HbA1c levels by using volume of interest analysis for brain areas relevant to appetite control. Voxel-based morphometry (VBM) of individual magnetic resonance imaging data was further performed to correlate grey matter density (GMD) maps with HbA1c. We found significant negative correlations between HbA1c levels and BP(ND) in right and left hippocampus in obesity (r = − 0.717, p < 0.001, and r = − 0.557, p = 0.006, respectively). VBM analyses revealed that higher HbA1c levels were associated with GMD in the right para-hippocampal area. Our results indicate that chronically high blood glucose levels may evoke changes in hippocampal 5-HTT levels that are in part tied to local microstructure. Nature Publishing Group UK 2020-12-07 /pmc/articles/PMC7721891/ /pubmed/33288788 http://dx.doi.org/10.1038/s41598-020-78227-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Grundmann, Rico Rullmann, Michael Luthardt, Julia Zientek, Franziska Becker, Georg-Alexander Patt, Marianne Hankir, Mohammed K. Blüher, Matthias Sabri, Osama Hesse, Swen Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity |
title | Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity |
title_full | Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity |
title_fullStr | Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity |
title_full_unstemmed | Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity |
title_short | Higher HbA1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity |
title_sort | higher hba1c levels associate with lower hippocampal serotonin transporter availability in non-diabetic adults with obesity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7721891/ https://www.ncbi.nlm.nih.gov/pubmed/33288788 http://dx.doi.org/10.1038/s41598-020-78227-z |
work_keys_str_mv | AT grundmannrico higherhba1clevelsassociatewithlowerhippocampalserotonintransporteravailabilityinnondiabeticadultswithobesity AT rullmannmichael higherhba1clevelsassociatewithlowerhippocampalserotonintransporteravailabilityinnondiabeticadultswithobesity AT luthardtjulia higherhba1clevelsassociatewithlowerhippocampalserotonintransporteravailabilityinnondiabeticadultswithobesity AT zientekfranziska higherhba1clevelsassociatewithlowerhippocampalserotonintransporteravailabilityinnondiabeticadultswithobesity AT beckergeorgalexander higherhba1clevelsassociatewithlowerhippocampalserotonintransporteravailabilityinnondiabeticadultswithobesity AT pattmarianne higherhba1clevelsassociatewithlowerhippocampalserotonintransporteravailabilityinnondiabeticadultswithobesity AT hankirmohammedk higherhba1clevelsassociatewithlowerhippocampalserotonintransporteravailabilityinnondiabeticadultswithobesity AT bluhermatthias higherhba1clevelsassociatewithlowerhippocampalserotonintransporteravailabilityinnondiabeticadultswithobesity AT sabriosama higherhba1clevelsassociatewithlowerhippocampalserotonintransporteravailabilityinnondiabeticadultswithobesity AT hesseswen higherhba1clevelsassociatewithlowerhippocampalserotonintransporteravailabilityinnondiabeticadultswithobesity |