Cargando…

Insulin directly stimulates mitochondrial glucose oxidation in the heart

BACKGROUND: Glucose oxidation is a major contributor to myocardial energy production and its contribution is orchestrated by insulin. While insulin can increase glucose oxidation indirectly by enhancing glucose uptake and glycolysis, it also directly stimulates mitochondrial glucose oxidation, indep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Karwi, Qutuba G., Wagg, Cory S., Altamimi, Tariq R., Uddin, Golam M., Ho, Kim L., Darwesh, Ahmed M., Seubert, John M., Lopaschuk, Gary D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722314/ https://www.ncbi.nlm.nih.gov/pubmed/33287820 http://dx.doi.org/10.1186/s12933-020-01177-3

Ejemplares similares

Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
por: Uddin, Golam M., et al.
Publicado: (2019)

Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction
por: Karwi, Qutuba G., et al.
Publicado: (2019)

Loss of Metabolic Flexibility in the Failing Heart
por: Karwi, Qutuba G., et al.
Publicado: (2018)

Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis
por: Gopal, Keshav, et al.
Publicado: (2023)

The Contribution of Cardiac Fatty Acid Oxidation to Diabetic Cardiomyopathy Severity
por: Karwi, Qutuba G., et al.
Publicado: (2021)

Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation
por: Gopal, Keshav, et al.
Publicado: (2023)

Pre- and postconditioning the heart with hydrogen sulfide (H(2)S) against ischemia/reperfusion injury in vivo: a systematic review and meta-analysis
por: Karwi, Qutuba G., et al.
Publicado: (2017)

Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction
por: Fillmore, Natasha, et al.
Publicado: (2018)

Inhibition of Carnitine Palmitoyltransferase-1 Activity Alleviates Insulin Resistance in Diet-Induced Obese Mice
por: Keung, Wendy, et al.
Publicado: (2013)

Inhibition of Soluble Epoxide Hydrolase Limits Mitochondrial Damage and Preserves Function Following Ischemic Injury
por: Akhnokh, Maria K., et al.
Publicado: (2016)

Mitochondrial Dysfunction and Inflammaging in Heart Failure: Novel Roles of CYP-Derived Epoxylipids
por: Keshavarz-Bahaghighat, Hedieh, et al.
Publicado: (2020)

Empagliflozin Increases Cardiac Energy Production in Diabetes: Novel Translational Insights Into the Heart Failure Benefits of SGLT2 Inhibitors
por: Verma, Subodh, et al.
Publicado: (2018)

Fasting increases susceptibility to acute myocardial ischaemia/reperfusion injury through a sirtuin-3 mediated increase in fatty acid oxidation
por: Hall, Andrew R., et al.
Publicado: (2022)

Influence of Molecular Weight and Degree of Deacetylation of Low Molecular Weight Chitosan on the Bioactivity of Oral Insulin Preparations
por: Qinna, Nidal A., et al.
Publicado: (2015)

Insulin-Stimulated Cardiac Glucose Oxidation Is Increased in High-Fat Diet–Induced Obese Mice Lacking Malonyl CoA Decarboxylase
por: Ussher, John R., et al.
Publicado: (2009)

Glucose and insulin levels are associated with arterial stiffness and concentric remodeling of the heart
por: Markus, Marcello Ricardo Paulista, et al.
Publicado: (2019)

Selective enhancement of cardiomyocyte efficiency results in a pernicious heart condition
por: Groenendyk, Jody, et al.
Publicado: (2020)

Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism
por: Manchenkov, Tania, et al.
Publicado: (2015)

An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion
por: McCommis, Kyle S., et al.
Publicado: (2016)

Insulin and glucose play a role in foam cell formation and function
por: Shashkin, Pavel N, et al.
Publicado: (2006)

Age and Sex Differences in Hearts of Soluble Epoxide Hydrolase Null Mice
por: Jamieson, K. Lockhart, et al.
Publicado: (2020)

The effects of postprandial glucose and insulin levels on postprandial endothelial function in subjects with normal glucose tolerance
por: Suzuki, Kazunari, et al.
Publicado: (2012)

The Aspergillus nidulans ATM Kinase Regulates Mitochondrial Function, Glucose Uptake and the Carbon Starvation Response
por: Krohn, Nadia Graciele, et al.
Publicado: (2013)

Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance
por: Gao, Su, et al.
Publicado: (2015)

Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?
por: Darwesh, Ahmed M., et al.
Publicado: (2021)

Activation of the Pleiotropic Drug Resistance Pathway Can Promote Mitochondrial DNA Retention by Fusion-Defective Mitochondria in Saccharomyces cerevisiae
por: Mutlu, Nebibe, et al.
Publicado: (2014)

Evidence for Amino Acid Snorkeling from a High-Resolution, In Vivo Analysis of Fis1 Tail-Anchor Insertion at the Mitochondrial Outer Membrane
por: Keskin, Abdurrahman, et al.
Publicado: (2017)

Endothelial cell injury by high glucose and heparanase is prevented by insulin, heparin and basic fibroblast growth factor
por: Han, Juying, et al.
Publicado: (2005)

Energy Metabolism on Mitochondrial Maturation and Its Effects on Cardiomyocyte Cell Fate
por: Persad, Kaya L., et al.
Publicado: (2022)

Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation
por: Darwesh, Ahmed M., et al.
Publicado: (2019)

Loss of PI3Kα Mediates Protection From Myocardial Ischemia–Reperfusion Injury Linked to Preserved Mitochondrial Function
por: Zhabyeyev, Pavel, et al.
Publicado: (2023)

Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors: A State-of-the-Art Review
por: Lopaschuk, Gary D., et al.
Publicado: (2020)

Sgs1 Binding to Rad51 Stimulates Homology-Directed DNA Repair in Saccharomyces cerevisiae
por: Campos-Doerfler, Lillian, et al.
Publicado: (2018)

Short-term high glucose exposure impairs insulin signaling in endothelial cells
por: De Nigris, Valeria, et al.
Publicado: (2015)

Targeting the Brain to Protect the Heart
por: Lopaschuk, Gary D.
Publicado: (2021)

Age, gender, insulin and blood glucose control status alter the risk of ischemic heart disease and stroke among elderly diabetic patients
por: Hayashi, Toshio, et al.
Publicado: (2011)

Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations With Risks of Psychosis and Depression in Young Adults
por: Perry, Benjamin I., et al.
Publicado: (2021)

Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets
por: Pizarro-Delgado, Javier, et al.
Publicado: (2016)

Insulin Augmentation of Glucose-Stimulated Insulin Secretion Is Impaired in Insulin-Resistant Humans
por: Halperin, Florencia, et al.
Publicado: (2012)

The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults
por: Barry, William E, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1bjkc5cu362m5n4a24ahatplo4