7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis

Within a backup program for the clinical investigational agent pretomanid (PA-824), scaffold hopping from delamanid inspired the discovery of a novel class of potent antitubercular agents that unexpectedly possessed notable utility against the kinetoplastid disease visceral leishmaniasis (VL). Follo...

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Detalles Bibliográficos
Autores principales: Thompson, Andrew M., O’Connor, Patrick D., Marshall, Andrew J., Yardley, Vanessa, Maes, Louis, Gupta, Suman, Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Franzblau, Scott G., Wan, Baojie, Wang, Yuehong, Ma, Zhenkun, Cooper, Christopher B., Denny, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: ACS Publications 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722354/
https://www.ncbi.nlm.nih.gov/pubmed/28459575
http://dx.doi.org/10.1021/acs.jmedchem.7b00034

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