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Citalopram intoxication in four week old infant

BACKGROUND: In contrast to intoxications in toddlers which can be due to accidental ingestions, many intoxications in infants are due to medication errors. To our knowledge, this is the first case report of a citalopram intoxication in an infant, and may offer new insight on possible screening metho...

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Autores principales: Janson, Jo-Anne, Wasylewicz, Arthur T. M., Eijkemans, Marianne, Kerskes, Marieke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722423/
https://www.ncbi.nlm.nih.gov/pubmed/33287753
http://dx.doi.org/10.1186/s12887-020-02439-5
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author Janson, Jo-Anne
Wasylewicz, Arthur T. M.
Eijkemans, Marianne
Kerskes, Marieke
author_facet Janson, Jo-Anne
Wasylewicz, Arthur T. M.
Eijkemans, Marianne
Kerskes, Marieke
author_sort Janson, Jo-Anne
collection PubMed
description BACKGROUND: In contrast to intoxications in toddlers which can be due to accidental ingestions, many intoxications in infants are due to medication errors. To our knowledge, this is the first case report of a citalopram intoxication in an infant, and may offer new insight on possible screening methods for intoxication as well as pharmacokinetics of citalopram in small infants. CASE PRESENTATION: This case report describes an unintentional citalopram intoxication in a 4 week old infant due to a vitamin D drops ‘look alike’ error. The infant showed extreme jitteriness and opisthotonus at presentation, as well as prolonged signs of gastro-oesophageal reflux. No cardiac rhythm disturbances or convulsions were seen. The clinical course combined with Finnegan scores was correlated to and supported by pharmacokinetic and pharmacokinetic data of citalopram in the patient. CONCLUSIONS: Using Finnegan scores in general pediatric practice could help objectify follow-up of acute intoxications in young infants with neurological symptoms. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-020-02439-5.
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spelling pubmed-77224232020-12-08 Citalopram intoxication in four week old infant Janson, Jo-Anne Wasylewicz, Arthur T. M. Eijkemans, Marianne Kerskes, Marieke BMC Pediatr Case Report BACKGROUND: In contrast to intoxications in toddlers which can be due to accidental ingestions, many intoxications in infants are due to medication errors. To our knowledge, this is the first case report of a citalopram intoxication in an infant, and may offer new insight on possible screening methods for intoxication as well as pharmacokinetics of citalopram in small infants. CASE PRESENTATION: This case report describes an unintentional citalopram intoxication in a 4 week old infant due to a vitamin D drops ‘look alike’ error. The infant showed extreme jitteriness and opisthotonus at presentation, as well as prolonged signs of gastro-oesophageal reflux. No cardiac rhythm disturbances or convulsions were seen. The clinical course combined with Finnegan scores was correlated to and supported by pharmacokinetic and pharmacokinetic data of citalopram in the patient. CONCLUSIONS: Using Finnegan scores in general pediatric practice could help objectify follow-up of acute intoxications in young infants with neurological symptoms. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-020-02439-5. BioMed Central 2020-12-07 /pmc/articles/PMC7722423/ /pubmed/33287753 http://dx.doi.org/10.1186/s12887-020-02439-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Janson, Jo-Anne
Wasylewicz, Arthur T. M.
Eijkemans, Marianne
Kerskes, Marieke
Citalopram intoxication in four week old infant
title Citalopram intoxication in four week old infant
title_full Citalopram intoxication in four week old infant
title_fullStr Citalopram intoxication in four week old infant
title_full_unstemmed Citalopram intoxication in four week old infant
title_short Citalopram intoxication in four week old infant
title_sort citalopram intoxication in four week old infant
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722423/
https://www.ncbi.nlm.nih.gov/pubmed/33287753
http://dx.doi.org/10.1186/s12887-020-02439-5
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