Effects of H3.3G34V mutation on genomic H3K36 and H3K27 methylation patterns in isogenic pediatric glioma cells

Histone H3.3 mutation (H3F3A) occurs in 50% of cortical pediatric high-grade gliomas. This mutation replaces glycine 34 with arginine or valine (G34R/V), impairing SETD2 activity (H3K36-specific trimethyltransferase). Consequently, reduced H3K36me3 is observed on H3.3G34V nucleosomes relative to wil...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Tina Yi-Ting, Piunti, Andrea, Qi, Jin, Morgan, Marc, Bartom, Elizabeth, Shilatifard, Ali, Saratsis, Amanda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722426/
https://www.ncbi.nlm.nih.gov/pubmed/33287886
http://dx.doi.org/10.1186/s40478-020-01092-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722426/
https://www.ncbi.nlm.nih.gov/pubmed/33287886
http://dx.doi.org/10.1186/s40478-020-01092-4

Ejemplares similares