Cargando…

Perioperative Dexmedetomidine attenuates brain ischemia reperfusion injury possibly via up-regulation of astrocyte Connexin 43

BACKGROUND: Astrocyte Connexin 43 (Cx43) is essential for the trophic and protective support of neurons during brain ischemia reperfusion (I/R) injury. It is believed that dexmedetomidine participates in Cx43-mediated effects. However, its mechanisms remained unclear. This study aims to address the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Xiaoyang, Cai, Xiaoying, Ye, Fang, Li, Ying, Wang, Qin, Zuo, Zhiyi, Huang, Wenqi, Wang, Zhongxing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722427/ https://www.ncbi.nlm.nih.gov/pubmed/33287729 http://dx.doi.org/10.1186/s12871-020-01211-7

Ejemplares similares

Perioperative aspirin improves neurological outcome after focal brain ischemia possibly via inhibition of Notch 1 in rat
por: Wang, Zhongxing, et al.
Publicado: (2014)

Evaluation of Connexin 43 Redistribution and Endocytosis in Astrocytes Subjected to Ischemia/Reperfusion or Oxygen-Glucose Deprivation and Reoxygenation
por: Xie, Hongyan, et al.
Publicado: (2017)

Propofol Mediated Protection of the Brain From Ischemia/Reperfusion Injury Through the Regulation of Microglial Connexin 43
por: Zhang, Tingting, et al.
Publicado: (2021)

Dexmedetomidine Attenuates Monocyte-Endothelial Adherence via Inhibiting Connexin43 on Vascular Endothelial Cells
por: Chai, Yunfei, et al.
Publicado: (2020)

Fluoxetin Upregulates Connexin 43 Expression in Astrocyte
por: Mostafavi, Hossein, et al.
Publicado: (2014)

Connexin 43 Controls the Astrocyte Immunoregulatory Phenotype
por: Boulay, Anne-Cécile, et al.
Publicado: (2018)

Vinpocetine Protects Against Cerebral Ischemia-Reperfusion Injury by Targeting Astrocytic Connexin43 via the PI3K/AKT Signaling Pathway
por: Zhao, Mingming, et al.
Publicado: (2020)

Effects of ischemic preconditioning on ischemia/reperfusion-induced arrhythmias by upregulatation of connexin 43 expression
por: Chen, Zhenguang, et al.
Publicado: (2011)

Antidepressants Impact Connexin 43 Channel Functions in Astrocytes
por: Jeanson, Tiffany, et al.
Publicado: (2016)

Connexin 43 dephosphorylation at serine 282 induces spontaneous arrhythmia and increases susceptibility to ischemia/reperfusion injury
por: Wu, Lulin, et al.
Publicado: (2023)

Effects of Pinocembrin Pretreatment on Connexin 43 (Cx43) Protein Expression After Rat Myocardial Ischemia-Reperfusion and Cardiac Arrhythmia
por: Zhang, Peng, et al.
Publicado: (2018)

Astrocytic Connexin43 Channels as Candidate Targets in Epilepsy Treatment
por: Walrave, Laura, et al.
Publicado: (2020)

Inhibition of Connexin 43 Hemichannels Alleviates Cerebral Ischemia/Reperfusion Injury via the TLR4 Signaling Pathway
por: Chen, Yingzhu, et al.
Publicado: (2018)

Mechanism of Mitochondrial Connexin43′s Protection of the Neurovascular Unit under Acute Cerebral Ischemia-Reperfusion Injury
por: Hou, Shuai, et al.
Publicado: (2016)

Connexin 43 gap junction-mediated astrocytic network reconstruction attenuates isoflurane-induced cognitive dysfunction in mice
por: Dong, Rui, et al.
Publicado: (2022)

Phosphorylation of astrocytic connexin43 by ERK1/2 impairs blood–brain barrier in acute cerebral ischemia
por: Chen, Wei, et al.
Publicado: (2017)

Roles of astrocytic connexin-43, hemichannels, and gap junctions in oxygen-glucose deprivation/reperfusion injury induced neuroinflammation and the possible regulatory mechanisms of salvianolic acid B and carbenoxolone
por: Yin, Xiang, et al.
Publicado: (2018)

Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease
por: Wang, Minghuan, et al.
Publicado: (2019)

Connexin43 Hemichannel-Mediated Regulation of Connexin43
por: Li, Kai, et al.
Publicado: (2013)

Integrin-Linked Kinase Activation Prevents Ventricular Arrhythmias Induced by Ischemia/Reperfusion Via Inhibition of Connexin 43 Remodeling
por: Zhou, Ping, et al.
Publicado: (2020)

A New Tool for In Vivo Study of Astrocyte Connexin 43 in Brain
por: Droguerre, Marine, et al.
Publicado: (2019)

The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 43()
por: Trevisan, Alexandre Maximiliano, et al.
Publicado: (2019)

Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice
por: Yang, Hui, et al.
Publicado: (2018)

Neuroprotective potential of imatinib in global ischemia-reperfusion-induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43
por: Wang, Jieying, et al.
Publicado: (2020)

Normobaric hyperoxia plays a neuroprotective role after cerebral ischemia by maintaining the redox homeostasis and the level of connexin43 in astrocytes
por: Qi, Zhifeng, et al.
Publicado: (2022)

Lipopolysaccharide Induces Degradation of Connexin43 in Rat Astrocytes via the Ubiquitin-Proteasome Proteolytic Pathway
por: Liao, Chih-Kai, et al.
Publicado: (2013)

Anti-arrhythmic effect of acupuncture pretreatment in the rats subjected to simulative global ischemia and reperfusion—involvement of intracellular Ca(2+) and connexin 43
por: Gao, Junhong, et al.
Publicado: (2015)

Dexmedetomidine combined with propofol attenuates myocardial ischemia/reperfusion injury by activating the AMPK signaling pathway
por: Yang, Ke, et al.
Publicado: (2023)

Gene microarray analysis of expression profiles in liver ischemia and reperfusion
por: Zheng, Xiaoyang, et al.
Publicado: (2017)

Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in vitro by inhibiting NLRP3 Inflammasome activation
por: Huang, Yaru, et al.
Publicado: (2021)

The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions
por: Liang, Zhen, et al.
Publicado: (2020)

The Application and Analytical Pathway of Dexmedetomidine in Ischemia/Reperfusion Injury
por: Tang, Ying, et al.
Publicado: (2019)

Effect of dexmedetomidine on lung ischemia-reperfusion injury
por: JIANG, LILI, et al.
Publicado: (2014)

Connexin 43/47 channels are important for astrocyte/oligodendrocyte cross-talk in myelination and demyelination
por: Basu, Rahul, et al.
Publicado: (2018)

The potential roles of stress‐induced phosphoprotein 1 and connexin 43 in rats with reperfusion arrhythmia
por: An, Li, et al.
Publicado: (2023)

Interaction of α Carboxyl Terminus 1 Peptide With the Connexin 43 Carboxyl Terminus Preserves Left Ventricular Function After Ischemia‐Reperfusion Injury
por: Jiang, Jingbo, et al.
Publicado: (2019)

Connexins in Astrocyte Migration
por: Lagos-Cabré, Raúl, et al.
Publicado: (2020)

Correction to: Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in vitro by inhibiting NLRP3 Inflammasome activation
por: Huang, Yaru, et al.
Publicado: (2021)

Connexin 26 and Connexin 43 in Canine Mammary Carcinoma
por: Luu, Savannah, et al.
Publicado: (2019)

Dexmedetomidine attenuates cerebral ischemia/reperfusion injury in neonatal rats by inhibiting TLR4 signaling
por: Cheng, Jiangxia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_qbv5rahviqsnrd813dvhpdk6q7