Apathy symptoms induced by low‐dose venlafaxine: Two cases

Recent guidelines regarding pharmacological interventions for major depressive disorder (MDD) recommend first using serotonin (5HT) selective reuptake inhibitors (SSRIs) or 5HT and norepinephrine (NE) reuptake inhibitors (SNRIs). Although SSRIs and SNRIs are effective and well‐tolerated, apathy occu...

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Autores principales: Sato, Shinji, Sodeyama, Noriko, Matsuzaki, Asaki, Shiratori, Yuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722648/
https://www.ncbi.nlm.nih.gov/pubmed/32267090
http://dx.doi.org/10.1002/npr2.12104
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author Sato, Shinji
Sodeyama, Noriko
Matsuzaki, Asaki
Shiratori, Yuki
author_facet Sato, Shinji
Sodeyama, Noriko
Matsuzaki, Asaki
Shiratori, Yuki
author_sort Sato, Shinji
collection PubMed
description Recent guidelines regarding pharmacological interventions for major depressive disorder (MDD) recommend first using serotonin (5HT) selective reuptake inhibitors (SSRIs) or 5HT and norepinephrine (NE) reuptake inhibitors (SNRIs). Although SSRIs and SNRIs are effective and well‐tolerated, apathy occurs as an adverse effect in some SSRIs‐treated patients. Because apathy would be associated with the 5HT pathway, if a patient exhibits apathy symptoms under SSRIs treatment, a clinical strategy has been to change the SSRIs to treatment with an SNRIs. Here, I report two cases in which low‐dose venlafaxine, an SNRIs, induced apathy symptoms.
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spelling pubmed-77226482020-12-08 Apathy symptoms induced by low‐dose venlafaxine: Two cases Sato, Shinji Sodeyama, Noriko Matsuzaki, Asaki Shiratori, Yuki Neuropsychopharmacol Rep Case Reports Recent guidelines regarding pharmacological interventions for major depressive disorder (MDD) recommend first using serotonin (5HT) selective reuptake inhibitors (SSRIs) or 5HT and norepinephrine (NE) reuptake inhibitors (SNRIs). Although SSRIs and SNRIs are effective and well‐tolerated, apathy occurs as an adverse effect in some SSRIs‐treated patients. Because apathy would be associated with the 5HT pathway, if a patient exhibits apathy symptoms under SSRIs treatment, a clinical strategy has been to change the SSRIs to treatment with an SNRIs. Here, I report two cases in which low‐dose venlafaxine, an SNRIs, induced apathy symptoms. John Wiley and Sons Inc. 2020-04-08 /pmc/articles/PMC7722648/ /pubmed/32267090 http://dx.doi.org/10.1002/npr2.12104 Text en © 2020 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Society of NeuropsychoPharmacology. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Sato, Shinji
Sodeyama, Noriko
Matsuzaki, Asaki
Shiratori, Yuki
Apathy symptoms induced by low‐dose venlafaxine: Two cases
title Apathy symptoms induced by low‐dose venlafaxine: Two cases
title_full Apathy symptoms induced by low‐dose venlafaxine: Two cases
title_fullStr Apathy symptoms induced by low‐dose venlafaxine: Two cases
title_full_unstemmed Apathy symptoms induced by low‐dose venlafaxine: Two cases
title_short Apathy symptoms induced by low‐dose venlafaxine: Two cases
title_sort apathy symptoms induced by low‐dose venlafaxine: two cases
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722648/
https://www.ncbi.nlm.nih.gov/pubmed/32267090
http://dx.doi.org/10.1002/npr2.12104
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AT matsuzakiasaki apathysymptomsinducedbylowdosevenlafaxinetwocases
AT shiratoriyuki apathysymptomsinducedbylowdosevenlafaxinetwocases

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