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Value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus

Cardiovascular disease is one of the main causes of death in diabetes mellitus (DM) patients. The aim of the current study was to explore the value of peak strain dispersion (PSD) for discovering early-stage left ventricular (LV) dysfunction in type 2 diabetes mellitus (T2DM) patients. One hundred a...

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Autores principales: Li, Chunmei, Yuan, Miao, Li, Kun, Bai, Wenjuan, Rao, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722717/
https://www.ncbi.nlm.nih.gov/pubmed/33293679
http://dx.doi.org/10.1038/s41598-020-78621-7
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author Li, Chunmei
Yuan, Miao
Li, Kun
Bai, Wenjuan
Rao, Li
author_facet Li, Chunmei
Yuan, Miao
Li, Kun
Bai, Wenjuan
Rao, Li
author_sort Li, Chunmei
collection PubMed
description Cardiovascular disease is one of the main causes of death in diabetes mellitus (DM) patients. The aim of the current study was to explore the value of peak strain dispersion (PSD) for discovering early-stage left ventricular (LV) dysfunction in type 2 diabetes mellitus (T2DM) patients. One hundred and one T2DM patients and sixty healthy subjects were selected for this study. T2DM patients were further divided into controlled blood glucose (HbA1c < 7%, n = 46) and uncontrolled blood glucose (HbA1c ≥ 7%, n = 55) subgroups. All participants underwent conventional echocardiography and two-dimensional speckle-tracking echocardiography. Our results showed that an obvious difference was not observed in global longitudinal strain (GLS) between the controlled blood glucose group and the control group (− 20.34% vs − 21.22%, P = 0.068). Compared with the healthy controls, the uncontrolled blood glucose group showed an impaired GLS (− 18.62% vs − 21.22%, P < 0.001). Nevertheless, PSD was appreciably increased in the controlled blood glucose group (36.02 ms vs 32.48 ms, P = 0.01) and uncontrolled blood glucose group (57.51 ms vs 32.48 ms, P < 0.001). Multivariate linear regression analysis showed that HbA1c was closely related to PSD lesion in the LV in the T2DM group (β = 0.520, P < 0.001). PSD plays an important role in evaluating the coordination and synchronization of myocardial movement and provides a more accurate and sensitive index assessment of early LV systolic function in T2DM patients. In addition, HbA1c levels were related to LV dysfunction.
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spelling pubmed-77227172020-12-09 Value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus Li, Chunmei Yuan, Miao Li, Kun Bai, Wenjuan Rao, Li Sci Rep Article Cardiovascular disease is one of the main causes of death in diabetes mellitus (DM) patients. The aim of the current study was to explore the value of peak strain dispersion (PSD) for discovering early-stage left ventricular (LV) dysfunction in type 2 diabetes mellitus (T2DM) patients. One hundred and one T2DM patients and sixty healthy subjects were selected for this study. T2DM patients were further divided into controlled blood glucose (HbA1c < 7%, n = 46) and uncontrolled blood glucose (HbA1c ≥ 7%, n = 55) subgroups. All participants underwent conventional echocardiography and two-dimensional speckle-tracking echocardiography. Our results showed that an obvious difference was not observed in global longitudinal strain (GLS) between the controlled blood glucose group and the control group (− 20.34% vs − 21.22%, P = 0.068). Compared with the healthy controls, the uncontrolled blood glucose group showed an impaired GLS (− 18.62% vs − 21.22%, P < 0.001). Nevertheless, PSD was appreciably increased in the controlled blood glucose group (36.02 ms vs 32.48 ms, P = 0.01) and uncontrolled blood glucose group (57.51 ms vs 32.48 ms, P < 0.001). Multivariate linear regression analysis showed that HbA1c was closely related to PSD lesion in the LV in the T2DM group (β = 0.520, P < 0.001). PSD plays an important role in evaluating the coordination and synchronization of myocardial movement and provides a more accurate and sensitive index assessment of early LV systolic function in T2DM patients. In addition, HbA1c levels were related to LV dysfunction. Nature Publishing Group UK 2020-12-08 /pmc/articles/PMC7722717/ /pubmed/33293679 http://dx.doi.org/10.1038/s41598-020-78621-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Li, Chunmei
Yuan, Miao
Li, Kun
Bai, Wenjuan
Rao, Li
Value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus
title Value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus
title_full Value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus
title_fullStr Value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus
title_full_unstemmed Value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus
title_short Value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus
title_sort value of peak strain dispersion in discovering left ventricular dysfunction in diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722717/
https://www.ncbi.nlm.nih.gov/pubmed/33293679
http://dx.doi.org/10.1038/s41598-020-78621-7
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