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Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea
Mature mammalian cochlear hair cells (HCs) do not spontaneously regenerate once lost, leading to life-long hearing deficits. Attempts to induce HC regeneration in adult mammals have used over-expression of the HC-specific transcription factor Atoh1, but to date this approach has yielded low and vari...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722738/ https://www.ncbi.nlm.nih.gov/pubmed/33293609 http://dx.doi.org/10.1038/s41598-020-78167-8 |