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A computational model for classification of BRCA2 variants using mouse embryonic stem cell-based functional assays

Sequencing-based genetic tests to identify individuals at increased risk of hereditary breast and ovarian cancers have resulted in the identification of more than 40,000 sequence variants of BRCA1 and BRCA2. A majority of these variants are considered to be variants of uncertain significance (VUS) b...

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Detalles Bibliográficos
Autores principales:	Biswas, Kajal, Lipton, Gary B., Stauffer, Stacey, Sullivan, Teresa, Cleveland, Linda, Southon, Eileen, Reid, Susan, Magidson, Valentin, Iversen, Edwin S., Sharan, Shyam K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722754/ https://www.ncbi.nlm.nih.gov/pubmed/33293522 http://dx.doi.org/10.1038/s41525-020-00158-5

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