SAMMY-seq reveals early alteration of heterochromatin and deregulation of bivalent genes in Hutchinson-Gilford Progeria Syndrome

Hutchinson-Gilford progeria syndrome is a genetic disease caused by an aberrant form of Lamin A resulting in chromatin structure disruption, in particular by interfering with lamina associated domains. Early molecular alterations involved in chromatin remodeling have not been identified thus far. He...

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Detalles Bibliográficos
Autores principales: Sebestyén, Endre, Marullo, Fabrizia, Lucini, Federica, Petrini, Cristiano, Bianchi, Andrea, Valsoni, Sara, Olivieri, Ilaria, Antonelli, Laura, Gregoretti, Francesco, Oliva, Gennaro, Ferrari, Francesco, Lanzuolo, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722762/
https://www.ncbi.nlm.nih.gov/pubmed/33293552
http://dx.doi.org/10.1038/s41467-020-20048-9

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