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Mouse–human co-clinical trials demonstrate superior anti-tumour effects of buparlisib (BKM120) and cetuximab combination in squamous cell carcinoma of head and neck

BACKGROUND: Recurrent and/or metastatic squamous cell carcinoma of head and neck (R/M SCCHN) is a common cancer with high recurrence and mortality. Current treatments have low response rates (RRs). METHODS: Fifty-three patients with R/M SCCHN received continuous oral buparlisib. In parallel, patient...

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Detalles Bibliográficos
Autores principales:	Kim, Hye Ryun, Kang, Han Na, Yun, Mi Ran, Ju, Kwon Young, Choi, Jae Woo, Jung, Dong Min, Pyo, Kyoung Ho, Hong, Min Hee, Ahn, Myoung-Ju, Sun, Jong-Mu, Kim, Han Sang, Kim, Jinna, Yoo, Jinseon, Kim, Kyu Ryung, Koh, Yoon Woo, Kim, Se Heon, Choi, Eun Chang, Yoon, Sun Ock, Shim, Hyo Sup, Paik, Soonmyung, Kim, Tae-Min, Cho, Byoung Chul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722843/ https://www.ncbi.nlm.nih.gov/pubmed/32963347 http://dx.doi.org/10.1038/s41416-020-01074-2

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