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Exploration of a novel virtual environment improves memory consolidation in ADHD
Experimental evidence in rodents and humans suggests that long-term memory consolidation can be enhanced by the exploration of a novel environment presented during a vulnerable early phase of consolidation. This memory enhancing effect (behavioral tagging) is caused by dopaminergic and noradrenergic...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722922/ https://www.ncbi.nlm.nih.gov/pubmed/33293595 http://dx.doi.org/10.1038/s41598-020-78222-4 |
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author | Baumann, Valentin Birnbaum, Thomas Breitling-Ziegler, Carolin Tegelbeckers, Jana Dambacher, Johannes Edelmann, Elke Bergado-Acosta, Jorge R. Flechtner, Hans-Henning Krauel, Kerstin |
author_facet | Baumann, Valentin Birnbaum, Thomas Breitling-Ziegler, Carolin Tegelbeckers, Jana Dambacher, Johannes Edelmann, Elke Bergado-Acosta, Jorge R. Flechtner, Hans-Henning Krauel, Kerstin |
author_sort | Baumann, Valentin |
collection | PubMed |
description | Experimental evidence in rodents and humans suggests that long-term memory consolidation can be enhanced by the exploration of a novel environment presented during a vulnerable early phase of consolidation. This memory enhancing effect (behavioral tagging) is caused by dopaminergic and noradrenergic neuromodulation of hippocampal plasticity processes. In translation from animal to human research, we investigated whether behavioral tagging with novelty can be used to tackle memory problems observed in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). 34 patients with ADHD and 34 typically developing participants (age 9–15 years) explored either a previously familiarized or a novel virtual environment 45 min after they had learned a list of 20 words. Participants took a free recall test both immediately after learning the word list and after 24 h. Patients who explored a familiar environment showed significantly impaired memory consolidation compared to typically developing peers. Exploration of a novel environment led to significantly better memory consolidation in children and adolescents with ADHD. However, we did not observe a beneficial effect of novel environment exploration in typically developing participants. Our data rather suggested that increased exploration of a novel environment as well as higher feelings of virtual immersion compromised memory performance in typically developing children and adolescents, which was not the case for patients with ADHD. We propose that behavioral tagging with novel virtual environments is a promising candidate to overcome ADHD related memory problems. Moreover, the discrepancy between children and adolescents with and without ADHD suggests that behavioral tagging might only be able to improve memory consolidation for weakly encoded information. |
format | Online Article Text |
id | pubmed-7722922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77229222020-12-09 Exploration of a novel virtual environment improves memory consolidation in ADHD Baumann, Valentin Birnbaum, Thomas Breitling-Ziegler, Carolin Tegelbeckers, Jana Dambacher, Johannes Edelmann, Elke Bergado-Acosta, Jorge R. Flechtner, Hans-Henning Krauel, Kerstin Sci Rep Article Experimental evidence in rodents and humans suggests that long-term memory consolidation can be enhanced by the exploration of a novel environment presented during a vulnerable early phase of consolidation. This memory enhancing effect (behavioral tagging) is caused by dopaminergic and noradrenergic neuromodulation of hippocampal plasticity processes. In translation from animal to human research, we investigated whether behavioral tagging with novelty can be used to tackle memory problems observed in children and adolescents with attention-deficit/hyperactivity disorder (ADHD). 34 patients with ADHD and 34 typically developing participants (age 9–15 years) explored either a previously familiarized or a novel virtual environment 45 min after they had learned a list of 20 words. Participants took a free recall test both immediately after learning the word list and after 24 h. Patients who explored a familiar environment showed significantly impaired memory consolidation compared to typically developing peers. Exploration of a novel environment led to significantly better memory consolidation in children and adolescents with ADHD. However, we did not observe a beneficial effect of novel environment exploration in typically developing participants. Our data rather suggested that increased exploration of a novel environment as well as higher feelings of virtual immersion compromised memory performance in typically developing children and adolescents, which was not the case for patients with ADHD. We propose that behavioral tagging with novel virtual environments is a promising candidate to overcome ADHD related memory problems. Moreover, the discrepancy between children and adolescents with and without ADHD suggests that behavioral tagging might only be able to improve memory consolidation for weakly encoded information. Nature Publishing Group UK 2020-12-08 /pmc/articles/PMC7722922/ /pubmed/33293595 http://dx.doi.org/10.1038/s41598-020-78222-4 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Baumann, Valentin Birnbaum, Thomas Breitling-Ziegler, Carolin Tegelbeckers, Jana Dambacher, Johannes Edelmann, Elke Bergado-Acosta, Jorge R. Flechtner, Hans-Henning Krauel, Kerstin Exploration of a novel virtual environment improves memory consolidation in ADHD |
title | Exploration of a novel virtual environment improves memory consolidation in ADHD |
title_full | Exploration of a novel virtual environment improves memory consolidation in ADHD |
title_fullStr | Exploration of a novel virtual environment improves memory consolidation in ADHD |
title_full_unstemmed | Exploration of a novel virtual environment improves memory consolidation in ADHD |
title_short | Exploration of a novel virtual environment improves memory consolidation in ADHD |
title_sort | exploration of a novel virtual environment improves memory consolidation in adhd |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722922/ https://www.ncbi.nlm.nih.gov/pubmed/33293595 http://dx.doi.org/10.1038/s41598-020-78222-4 |
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