CRISPR/Cas9 genome-wide loss-of-function screening identifies druggable cellular factors involved in sunitinib resistance in renal cell carcinoma

BACKGROUND: Multi-targeted tyrosine kinase inhibitors (TKIs) are the standard of care for patients with advanced clear cell renal cell carcinoma (ccRCC). However, a significant number of ccRCC patients are primarily refractory to targeted therapeutics, showing neither disease stabilisation nor clini...

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Detalles Bibliográficos
Autores principales: Makhov, Peter, Sohn, Ji A., Serebriiskii, Ilya G., Fazliyeva, Rushaniya, Khazak, Vladimir, Boumber, Yanis, Uzzo, Robert G., Kolenko, Vladimir M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723036/
https://www.ncbi.nlm.nih.gov/pubmed/32968206
http://dx.doi.org/10.1038/s41416-020-01087-x

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