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Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females

Cardiorespiratory fitness (CRF) and endurance performance are characterized by a complex genetic trait with high heritability. Although research has identified many physiological and environmental correlates with CRF, the genetic architecture contributing to CRF remains unclear, especially in non-at...

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Autores principales: Zhao, Ying, Huang, Guoyuan, Chen, Zuosong, Fan, Xiang, Huang, Tao, Liu, Jinsheng, Zhang, Qing, Shen, Jingyi, Li, Zhiqiang, Shi, Yongyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723046/
https://www.ncbi.nlm.nih.gov/pubmed/32572135
http://dx.doi.org/10.1038/s41598-020-67045-y
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author Zhao, Ying
Huang, Guoyuan
Chen, Zuosong
Fan, Xiang
Huang, Tao
Liu, Jinsheng
Zhang, Qing
Shen, Jingyi
Li, Zhiqiang
Shi, Yongyong
author_facet Zhao, Ying
Huang, Guoyuan
Chen, Zuosong
Fan, Xiang
Huang, Tao
Liu, Jinsheng
Zhang, Qing
Shen, Jingyi
Li, Zhiqiang
Shi, Yongyong
author_sort Zhao, Ying
collection PubMed
description Cardiorespiratory fitness (CRF) and endurance performance are characterized by a complex genetic trait with high heritability. Although research has identified many physiological and environmental correlates with CRF, the genetic architecture contributing to CRF remains unclear, especially in non-athlete population. A total of 762 Chinese young female participants were recruited and an endurance run test was used to determine CRF. We used a fixed model of genome-wide association studies (GWAS) for CRF. Genotyping was performed using the Affymetrix Axiom and illumina 1 M arrays. After quality control and imputation, a linear regression-based association analysis was conducted using a total of 5,149,327 variants. Four loci associated with CRF were identified to reach genome-wide significance (P < 5.0 × 10(-8)), which located in 15q21.3 (rs17240160, P = 1.73 × 10(-9), GCOM1), 3q25.31 (rs819865, P = 8.56 × 10(-9), GMPS), 21q22.3 (rs117828698, P = 9.59 × 10(-9), COL18A1), and 17q24.2 (rs79806428, P = 3.85 × 10(-8), PRKCA). These loci (GCOM1, GMPS, COL18A1 and PRKCA) associated with cardiorespiratory fitness and endurance performance in Chinese non-athlete young females. Our results suggest that these gene polymorphisms provide further genetic evidence for the polygenetic nature of cardiorespiratory endurance and be used as genetic biomarkers for future research.
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spelling pubmed-77230462020-12-09 Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females Zhao, Ying Huang, Guoyuan Chen, Zuosong Fan, Xiang Huang, Tao Liu, Jinsheng Zhang, Qing Shen, Jingyi Li, Zhiqiang Shi, Yongyong Sci Rep Article Cardiorespiratory fitness (CRF) and endurance performance are characterized by a complex genetic trait with high heritability. Although research has identified many physiological and environmental correlates with CRF, the genetic architecture contributing to CRF remains unclear, especially in non-athlete population. A total of 762 Chinese young female participants were recruited and an endurance run test was used to determine CRF. We used a fixed model of genome-wide association studies (GWAS) for CRF. Genotyping was performed using the Affymetrix Axiom and illumina 1 M arrays. After quality control and imputation, a linear regression-based association analysis was conducted using a total of 5,149,327 variants. Four loci associated with CRF were identified to reach genome-wide significance (P < 5.0 × 10(-8)), which located in 15q21.3 (rs17240160, P = 1.73 × 10(-9), GCOM1), 3q25.31 (rs819865, P = 8.56 × 10(-9), GMPS), 21q22.3 (rs117828698, P = 9.59 × 10(-9), COL18A1), and 17q24.2 (rs79806428, P = 3.85 × 10(-8), PRKCA). These loci (GCOM1, GMPS, COL18A1 and PRKCA) associated with cardiorespiratory fitness and endurance performance in Chinese non-athlete young females. Our results suggest that these gene polymorphisms provide further genetic evidence for the polygenetic nature of cardiorespiratory endurance and be used as genetic biomarkers for future research. Nature Publishing Group UK 2020-06-22 /pmc/articles/PMC7723046/ /pubmed/32572135 http://dx.doi.org/10.1038/s41598-020-67045-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhao, Ying
Huang, Guoyuan
Chen, Zuosong
Fan, Xiang
Huang, Tao
Liu, Jinsheng
Zhang, Qing
Shen, Jingyi
Li, Zhiqiang
Shi, Yongyong
Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females
title Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females
title_full Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females
title_fullStr Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females
title_full_unstemmed Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females
title_short Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females
title_sort four loci are associated with cardiorespiratory fitness and endurance performance in young chinese females
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723046/
https://www.ncbi.nlm.nih.gov/pubmed/32572135
http://dx.doi.org/10.1038/s41598-020-67045-y
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