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Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females
Cardiorespiratory fitness (CRF) and endurance performance are characterized by a complex genetic trait with high heritability. Although research has identified many physiological and environmental correlates with CRF, the genetic architecture contributing to CRF remains unclear, especially in non-at...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723046/ https://www.ncbi.nlm.nih.gov/pubmed/32572135 http://dx.doi.org/10.1038/s41598-020-67045-y |
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author | Zhao, Ying Huang, Guoyuan Chen, Zuosong Fan, Xiang Huang, Tao Liu, Jinsheng Zhang, Qing Shen, Jingyi Li, Zhiqiang Shi, Yongyong |
author_facet | Zhao, Ying Huang, Guoyuan Chen, Zuosong Fan, Xiang Huang, Tao Liu, Jinsheng Zhang, Qing Shen, Jingyi Li, Zhiqiang Shi, Yongyong |
author_sort | Zhao, Ying |
collection | PubMed |
description | Cardiorespiratory fitness (CRF) and endurance performance are characterized by a complex genetic trait with high heritability. Although research has identified many physiological and environmental correlates with CRF, the genetic architecture contributing to CRF remains unclear, especially in non-athlete population. A total of 762 Chinese young female participants were recruited and an endurance run test was used to determine CRF. We used a fixed model of genome-wide association studies (GWAS) for CRF. Genotyping was performed using the Affymetrix Axiom and illumina 1 M arrays. After quality control and imputation, a linear regression-based association analysis was conducted using a total of 5,149,327 variants. Four loci associated with CRF were identified to reach genome-wide significance (P < 5.0 × 10(-8)), which located in 15q21.3 (rs17240160, P = 1.73 × 10(-9), GCOM1), 3q25.31 (rs819865, P = 8.56 × 10(-9), GMPS), 21q22.3 (rs117828698, P = 9.59 × 10(-9), COL18A1), and 17q24.2 (rs79806428, P = 3.85 × 10(-8), PRKCA). These loci (GCOM1, GMPS, COL18A1 and PRKCA) associated with cardiorespiratory fitness and endurance performance in Chinese non-athlete young females. Our results suggest that these gene polymorphisms provide further genetic evidence for the polygenetic nature of cardiorespiratory endurance and be used as genetic biomarkers for future research. |
format | Online Article Text |
id | pubmed-7723046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-77230462020-12-09 Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females Zhao, Ying Huang, Guoyuan Chen, Zuosong Fan, Xiang Huang, Tao Liu, Jinsheng Zhang, Qing Shen, Jingyi Li, Zhiqiang Shi, Yongyong Sci Rep Article Cardiorespiratory fitness (CRF) and endurance performance are characterized by a complex genetic trait with high heritability. Although research has identified many physiological and environmental correlates with CRF, the genetic architecture contributing to CRF remains unclear, especially in non-athlete population. A total of 762 Chinese young female participants were recruited and an endurance run test was used to determine CRF. We used a fixed model of genome-wide association studies (GWAS) for CRF. Genotyping was performed using the Affymetrix Axiom and illumina 1 M arrays. After quality control and imputation, a linear regression-based association analysis was conducted using a total of 5,149,327 variants. Four loci associated with CRF were identified to reach genome-wide significance (P < 5.0 × 10(-8)), which located in 15q21.3 (rs17240160, P = 1.73 × 10(-9), GCOM1), 3q25.31 (rs819865, P = 8.56 × 10(-9), GMPS), 21q22.3 (rs117828698, P = 9.59 × 10(-9), COL18A1), and 17q24.2 (rs79806428, P = 3.85 × 10(-8), PRKCA). These loci (GCOM1, GMPS, COL18A1 and PRKCA) associated with cardiorespiratory fitness and endurance performance in Chinese non-athlete young females. Our results suggest that these gene polymorphisms provide further genetic evidence for the polygenetic nature of cardiorespiratory endurance and be used as genetic biomarkers for future research. Nature Publishing Group UK 2020-06-22 /pmc/articles/PMC7723046/ /pubmed/32572135 http://dx.doi.org/10.1038/s41598-020-67045-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Zhao, Ying Huang, Guoyuan Chen, Zuosong Fan, Xiang Huang, Tao Liu, Jinsheng Zhang, Qing Shen, Jingyi Li, Zhiqiang Shi, Yongyong Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females |
title | Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females |
title_full | Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females |
title_fullStr | Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females |
title_full_unstemmed | Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females |
title_short | Four Loci Are Associated with Cardiorespiratory Fitness and Endurance Performance in Young Chinese Females |
title_sort | four loci are associated with cardiorespiratory fitness and endurance performance in young chinese females |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723046/ https://www.ncbi.nlm.nih.gov/pubmed/32572135 http://dx.doi.org/10.1038/s41598-020-67045-y |
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