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Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes

Resveratrol is a representative polyphenol of diet-derived putative cancer chemopreventive agents, which have attracted increasing interest in the cancer chemoprevention community. The inhibition of the action of human papillomavirus (HPV) E6 and E7 has been considered a key approach for cervical ca...

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Autores principales: Sun, Xiaodong, Fu, Pan, Xie, Lixia, Chai, Senmao, Xu, Qianqian, Zeng, Lian, Wang, Xuanbin, Jiang, Nan, Sang, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723400/
https://www.ncbi.nlm.nih.gov/pubmed/33236130
http://dx.doi.org/10.3892/ijmm.2020.4789
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author Sun, Xiaodong
Fu, Pan
Xie, Lixia
Chai, Senmao
Xu, Qianqian
Zeng, Lian
Wang, Xuanbin
Jiang, Nan
Sang, Ming
author_facet Sun, Xiaodong
Fu, Pan
Xie, Lixia
Chai, Senmao
Xu, Qianqian
Zeng, Lian
Wang, Xuanbin
Jiang, Nan
Sang, Ming
author_sort Sun, Xiaodong
collection PubMed
description Resveratrol is a representative polyphenol of diet-derived putative cancer chemopreventive agents, which have attracted increasing interest in the cancer chemoprevention community. The inhibition of the action of human papillomavirus (HPV) E6 and E7 has been considered a key approach for cervical cancer therapy. Resveratrol has been shown to induce the apoptosis, and reduce both the viability and mitotic index of a number of cancer cell lines, including human cervical cancer cells. In the present study, it was confirmed that resveratrol inhibited the HPV E6 mRNA, HPV E6 protein and phosphorylated retinoblastoma protein (p-pRb1) levels, and increased the p53 protein levels in HeLa and Ca Ski cells, as well as in subcutaneous tumor tissue grown from HeLa cells. High-risk HPV uses a bicistronic RNA to control E6 and E7 genes simultaneously. On the whole, the present study demonstrates that resveratrol inhibits cervical cancer development by suppressing the transcription and translation of E6 and E7, and also by promoting the apoptosis and G1/S phase transition arrest. These findings may provide the basis for the development of resveratrol as a candidate for cervical cancer therapy.
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spelling pubmed-77234002020-12-23 Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes Sun, Xiaodong Fu, Pan Xie, Lixia Chai, Senmao Xu, Qianqian Zeng, Lian Wang, Xuanbin Jiang, Nan Sang, Ming Int J Mol Med Articles Resveratrol is a representative polyphenol of diet-derived putative cancer chemopreventive agents, which have attracted increasing interest in the cancer chemoprevention community. The inhibition of the action of human papillomavirus (HPV) E6 and E7 has been considered a key approach for cervical cancer therapy. Resveratrol has been shown to induce the apoptosis, and reduce both the viability and mitotic index of a number of cancer cell lines, including human cervical cancer cells. In the present study, it was confirmed that resveratrol inhibited the HPV E6 mRNA, HPV E6 protein and phosphorylated retinoblastoma protein (p-pRb1) levels, and increased the p53 protein levels in HeLa and Ca Ski cells, as well as in subcutaneous tumor tissue grown from HeLa cells. High-risk HPV uses a bicistronic RNA to control E6 and E7 genes simultaneously. On the whole, the present study demonstrates that resveratrol inhibits cervical cancer development by suppressing the transcription and translation of E6 and E7, and also by promoting the apoptosis and G1/S phase transition arrest. These findings may provide the basis for the development of resveratrol as a candidate for cervical cancer therapy. D.A. Spandidos 2021-01 2020-11-17 /pmc/articles/PMC7723400/ /pubmed/33236130 http://dx.doi.org/10.3892/ijmm.2020.4789 Text en Copyright: © Sun et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Sun, Xiaodong
Fu, Pan
Xie, Lixia
Chai, Senmao
Xu, Qianqian
Zeng, Lian
Wang, Xuanbin
Jiang, Nan
Sang, Ming
Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes
title Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes
title_full Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes
title_fullStr Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes
title_full_unstemmed Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes
title_short Resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of HPV E6 and E7 genes
title_sort resveratrol inhibits the progression of cervical cancer by suppressing the transcription and expression of hpv e6 and e7 genes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723400/
https://www.ncbi.nlm.nih.gov/pubmed/33236130
http://dx.doi.org/10.3892/ijmm.2020.4789
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