SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis

Mutations of SMC5/6 components cause developmental defects, including primary microcephaly. To model neurodevelopmental defects, we engineered a mouse wherein Smc5 is conditionally knocked out (cKO) in the developing neocortex. Smc5 cKO mice exhibited neurodevelopmental defects due to neural progeni...

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Detalles Bibliográficos
Autores principales: Atkins, Alisa, Xu, Michelle J, Li, Maggie, Rogers, Nathaniel P, Pryzhkova, Marina V, Jordan, Philip W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723410/
https://www.ncbi.nlm.nih.gov/pubmed/33200984
http://dx.doi.org/10.7554/eLife.61171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723410/
https://www.ncbi.nlm.nih.gov/pubmed/33200984
http://dx.doi.org/10.7554/eLife.61171

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