Pimozide augments bromocriptine lethality in prolactinoma cells and in a xenograft model via the STAT5/cyclin D1 and STAT5/Bcl-xL signaling pathways

As hyperprolactinemia is observed in patients with bromocriptine-resistant prolactinoma, prolactin (PRL) has been implicated in the development of bromocriptine resistance. Since PRL primarily mediates cell survival and drug resistance via the Janus kinase-2 (JAK2)/signal transducer and activator of...

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Detalles Bibliográficos
Autores principales: Xiao, Zhengzheng, Liang, Jing, Deng, Qing, Song, Chaojun, Yang, Xiaoli, Liu, Zebin, Shao, Zheng, Zhang, Kun, Wang, Xiaobin, Li, Zhengwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723514/
https://www.ncbi.nlm.nih.gov/pubmed/33155660
http://dx.doi.org/10.3892/ijmm.2020.4784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7723514/
https://www.ncbi.nlm.nih.gov/pubmed/33155660
http://dx.doi.org/10.3892/ijmm.2020.4784

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